- Miconazole protects blood vessels from MMP9-dependent rupture and hemorrhage.
Miconazole protects blood vessels from MMP9-dependent rupture and hemorrhage.
Disease models & mechanisms (2017-02-06)
Ran Yang, Yunpei Zhang, Dandan Huang, Xiao Luo, Liangren Zhang, Xiaojun Zhu, Xiaolin Zhang, Zhenming Liu, Jing-Yan Han, Jing-Wei Xiong
PMID28153846
要旨
Hemorrhagic stroke accounts for 10-15% of all strokes and is strongly associated with mortality and morbidity worldwide, but its prevention and therapeutic interventions remain a major challenge. Here, we report the identification of miconazole as a hemorrhagic suppressor by a small-molecule screen in zebrafish. We found that a hypomorphic mutant
材料
製品番号
ブランド
製品内容
Sigma-Aldrich
MMP-9 Inhibitor II, The MMP-9 Inhibitor II controls the biological activity of MMP-9. This small molecule/inhibitor is primarily used for Biochemicals applications.