Highly enantioselective conjugate addition of nitromethane to chalcones using bifunctional cinchona organocatalysts.

Highly enantioselective conjugate addition of nitromethane to chalcones using bifunctional cinchona organocatalysts.

Organic letters (2005-05-07)

Benedek Vakulya, Szilárd Varga, Antal Csámpai, Tibor Soós

要旨

Cinchona alkaloid-derived chiral bifunctional thiourea organocatalysts were synthesized and applied in the Michael addition between nitromethane and chalcones with high ee and chemical yields.

材料

製品番号

ブランド

製品内容

360554

Sigma-Aldrich

ニトロメタン, ACS reagent, ≥95%

230731

Sigma-Aldrich

ニトロメタン, ReagentPlus^®, ≥99.0%

270423

Sigma-Aldrich

ニトロメタン, suitable for HPLC, ≥96%

690481

Sigma-Aldrich

N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8a,9S)-6′-methoxy-9-cinchonanyl]thiourea, 90%

690384

Sigma-Aldrich

N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8a,9S)-10,11-dihydro-6′-methoxy-9-cinchonanyl]thiourea, 90%

73478

Sigma-Aldrich

ニトロメタン, puriss., absolute, over molecular sieve, ≥98.5% (GC)