コンテンツへスキップ

Impact of copper-catalyzed cross-coupling reactions in natural product synthesis: the emergence of new retrosynthetic paradigms.

Impact of copper-catalyzed cross-coupling reactions in natural product synthesis: the emergence of new retrosynthetic paradigms.

Natural product reports (2013-10-25)

Gwilherm Evano, Cédric Theunissen, Alexandre Pradal

要旨

Copper-catalyzed Ullmann-Goldberg-type cross-coupling reactions have undergone nothing short of a renaissance over the last decade and an impressive number of procedures are now available for the formation of C-N, C-O and C-S bonds with remarkable efficiencies and surgical precision. These reactions have been recently integrated into natural product synthesis, which clearly resulted in the emergence of new retrosynthetic paradigms and bond disconnections. The impact of copper-catalyzed cross-coupling reactions in natural product synthesis will be overviewed in this article with an emphasis on the evolution of strategies due to copper catalysis, mostly by comparison with alternative tactics and their relative efficiencies.

材料

製品番号

ブランド

製品内容

Sigma-Aldrich

銅, powder, 99.999% trace metals basis

Sigma-Aldrich

銅, foil, thickness 0.25 mm, 99.98% trace metals basis

Sigma-Aldrich

銅, powder, <425 μm, 99.5% trace metals basis

Sigma-Aldrich

銅, wire, diam. 1.0 mm, ≥99.9%

Sigma-Aldrich

銅, powder, <75 μm, 99%

Sigma-Aldrich

銅, nanopowder, 40-60 nm particle size (SAXS), ≥99.5% trace metals basis

Sigma-Aldrich

銅, powder (spheroidal), 10-25 μm, 98%

Sigma-Aldrich

銅, wire, diam. 0.25 mm, 99.999% trace metals basis

Sigma-Aldrich

銅, nanopowder, 60-80 nm particle size (SAXS), ≥99.5% trace metals basis

Sigma-Aldrich

銅, foil, thickness 0.025 mm, 99.98% trace metals basis

Sigma-Aldrich

銅, turnings, purum p.a., ≥99.0%

Sigma-Aldrich

銅, foil, ≥99.8% (complexometric)

Sigma-Aldrich

銅, powder (dendritic), <45 μm, 99.7% trace metals basis

Sigma-Aldrich

銅, wire, diam. 0.64 mm, 99.995% trace metals basis

Sigma-Aldrich

銅, foil, thickness 0.5 mm, 99.98% trace metals basis

Sigma-Aldrich

銅, shot, −3-+14 mesh, 99%

Sigma-Aldrich

銅, foil, thickness 1.0 mm, 99.999% trace metals basis

銅, mesh, 100x100mm, nominal aperture 0.14mm, thickness 0.25mm, wire diameter 0.115mm, 100x100 wires/inch, open area 30.3%, plain weave mesh

銅, rod, 100mm, diameter 9.5mm, hard, 99.9%

Sigma-Aldrich

銅, beads, 2-8 mm, 99.9995% trace metals basis

Sigma-Aldrich

銅, wire, diam. 2.0 mm, 99.999% trace metals basis

Sigma-Aldrich

銅, beads, 2-8 mm, ≥99.99% trace metals basis

銅, tube, 100mm, outside diameter 3.5mm, inside diameter 1.56mm, wall thickness 0.97mm, as drawn, 99.9%

銅, tube, 500mm, outside diameter 6.35mm, inside diameter 4.93mm, wall thickness 0.71mm, as drawn, 99.9%

銅, rod, 50mm, diameter 6.35mm, as drawn, 99.999%

Sigma-Aldrich

銅, ACS reagent, granular, 10-40 mesh, ≥99.90%

銅, rod, 50mm, diameter 12.7mm, as drawn, 99.99+%

銅, rod, 1000mm, diameter 4.8mm, hard, 99.9%

銅- O.F.H.C., sheet, 150x150mm, thickness 3.0mm, 99.95+%

銅, rod, 200mm, diameter 8.0mm, as drawn, 99.99+%