[Methods for the protection against counterfeit medications. Part 2. The assessment of interlot dispersion of the metoprolol succinate tablets fabricated by different manufacturers].

[Methods for the protection against counterfeit medications. Part 2. The assessment of interlot dispersion of the metoprolol succinate tablets fabricated by different manufacturers].

Sudebno-meditsinskaia ekspertiza (2013-01-01)

V A Iakushev, M A Morozova, T E Elizarova, S B Fitilev, T V Pletneva

要旨

This paper reports the results of analysis of the metoprolol succinate tablets fabricated by two different manufacturers, Akrikhin (Russia) and AstraZeneka (Sweden) by near-IR spectroscopy in the combination with the chemometric processing of the data obtained (discriminative analysis). It is concluded that this method is applicable for the assessment of interlot dispersion of the metoprolol succinate tablets.

材料

製品番号

ブランド

製品内容

M5391

Sigma-Aldrich

(±)-メトプロロール (+)-酒石酸塩, ≥98% (titration), powder

M-123

Supelco

Metoprolol tartrate solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant^®

PHR1076

Supelco

(±)-メトプロロール (+)-酒石酸塩, Pharmaceutical Secondary Standard; Certified Reference Material

M1830000

(±)-メトプロロール (+)-酒石酸塩, European Pharmacopoeia (EP) Reference Standard