Improved chemical stabilities for end-capped high performance liquid chromatography stationary phases based on poly(methyloctadecylsiloxane) thermally immobilized onto metalized silicas.

Improved chemical stabilities for end-capped high performance liquid chromatography stationary phases based on poly(methyloctadecylsiloxane) thermally immobilized onto metalized silicas.

Journal of chromatography. A (2012-09-12)

Carla G A da Silva, Carol H Collins

要旨

Endcapped stationary phases were prepared after thermal immobilization of poly(methyloctadecylsiloxane) (PMODS) onto zirconized and titanized silica supports. These new stationary phases have lower densities of residual hydroxyl groups, according to infrared spectroscopy and 29Si CP-MAS NMR and as shown by the symmetrical peaks of basic compounds from the Tanaka, Engelhardt and SRM 870 test mixtures. Stability tests for the endcapped stationary phases, measured using severe alkaline conditions (70:30 (v/v) methanol:0.05 mol/L K2CO3/KHCO3, pH 10, 50 °C), revealed that the stabilities of these phases are greater than the stabilities of similar nonendcapped phases. The stationary phases showed good performance for the separation of basic pharmaceuticals.

材料

製品番号

ブランド

製品内容

E12508

Sigma-Aldrich

エチルベンゼン, ReagentPlus^®, 99%

487104

Supelco

エチルベンゼン溶液, NMR reference standard, 0.1% in chloroform-d (99.8 atom % D), TMS 0.01 %, NMR tube size 5 mm × 8 in.

296848

Sigma-Aldrich

エチルベンゼン, anhydrous, 99.8%

736198

Supelco

エチルベンゼン溶液, NMR reference standard, 10% in chloroform-d (99.8 atom % D), NMR tube size 5 mm × 8 in. , ultra-thin wall

708046

Sigma-Aldrich

エチルベンゼン溶液, NMR reference standard, 10% in chloroform-d (99.8 atom % D)

03079

Supelco

エチルベンゼン, analytical standard

717959

Sigma-Aldrich

エチルベンゼン溶液, NMR reference standard, 1% in chloroform-d (99.8 atom % D)

714917

Sigma-Aldrich

エチルベンゼン溶液, NMR reference standard, 0.1% in chloroform-d (99.8 atom % D), TMS 0.01 %, NMR tube size 5 mm × 8 in. , ultra-thin wall

612065

Sigma-Aldrich

エチルベンゼン溶液, NMR reference standard, 0.1% in chloroform-d (99.8 atom % D), TMS 0.01 %, NMR tube size 10 mm × 8 in.

708054

Sigma-Aldrich

エチルベンゼン溶液, NMR reference standard, 0.1% in chloroform-d ("100%", 99.96 atom % D)

551341

Sigma-Aldrich

エチルベンゼン溶液, NMR reference standard, 5% in chloroform-d (99.8 atom % D), TMS 2 %, NMR tube size 5 mm × 8 in.

487120

Sigma-Aldrich

エチルベンゼン溶液, NMR reference standard, 0.1% in chloroform-d (99.8 atom % D), TMS 0.01 %, NMR tube size 8 mm × 8 in.