- Pd-NHC catalyzed conjugate addition versus the Mizoroki-Heck reaction.
Pd-NHC catalyzed conjugate addition versus the Mizoroki-Heck reaction.
Chemistry (Weinheim an der Bergstrasse, Germany) (2011-02-10)
Aditya L Gottumukkala, Johannes G de Vries, Adriaan J Minnaard
PMID21305628
要旨
Ace of base: A catalytic system is presented that, solely by choice of the base, selectively switches between conjugate addition and the Mizoroki-Heck reaction of aryl halides with Michael acceptors (see scheme; R, R' = alkyl, aryl). For conjugate addition reactions, this avoids the preparation and use of organometallics.