- Transaminations with isopropyl amine: equilibrium displacement with yeast alcohol dehydrogenase coupled to in situ cofactor regeneration.
Transaminations with isopropyl amine: equilibrium displacement with yeast alcohol dehydrogenase coupled to in situ cofactor regeneration.
Chemical communications (Cambridge, England) (2010-05-13)
Karim Engelmark Cassimjee, Cecilia Branneby, Vahak Abedi, Andrew Wells, Per Berglund
PMID20461279
要旨
Enantiopure chiral amines synthesis using omega-transaminases is hindered by an unfavourable equilibrium, but when using isopropylamine as the amine donor the equilibrium can be completely displaced by using a specific dehydrogenase in situ for removal of formed acetone.