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  • Ocotea quixos Lam. essential oil: in vitro and in vivo investigation on its anti-inflammatory properties.

Ocotea quixos Lam. essential oil: in vitro and in vivo investigation on its anti-inflammatory properties.

Fitoterapia (2009-10-15)
Vigilio Ballabeni, Massimiliano Tognolini, Carmine Giorgio, Simona Bertoni, Renato Bruni, Elisabetta Barocelli
要旨

Here we investigated the anti-inflammatory properties of Ocotea quixos essential oil and of its main components, trans-cinnamaldehyde and methyl cinnamate, in in vitro and in vivo models. Ocotea essential oil and trans-cinnamaldehyde but not methyl cinnamate significantly reduced LPS-induced NO release from J774 macrophages at non-toxic concentrations, inhibited LPS-induced COX-2 expression and increased forskolin-induced cAMP production. The essential oil (30-100mg/kg os) and trans-cinnamaldehyde (10mg/kg os) in carrageenan-induced rat paw edema showed anti-inflammatory effect without damaging gastric mucosa. In conclusion we provide the first evidence of a significant anti-inflammatory gastro-sparing activity of O.quixos essential oil.

材料
製品番号
ブランド
製品内容

Sigma-Aldrich
桂皮酸メチル, natural, ≥98%, FCC, FG
Sigma-Aldrich
trans-桂皮酸メチル, 99%
Sigma-Aldrich
桂皮酸メチル, ≥99.0% (GC)