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Merck

Dengue infection in pregnancy and its impact on the placenta.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases (2017-01-16)
Christiane Fernandes Ribeiro, Vânia Glória Silami Lopes, Patrícia Brasil, Andrea Rodrigues Cordovil Pires, Roger Rohloff, Rita Maria Ribeiro Nogueira
要旨

A histopathological and immunohistochemical study was conducted in placental tissues and retained products of conception from 24 patients with confirmed dengue infection during pregnancy. The immunohistochemical assay was positive for dengue virus in 19 placental and three ovular remnants analyzed. The light microscopic findings were signs of hypoxia, choriodeciduitis, deciduitis and intervillositis and the viral antigens were found in cytoplasmic of the trophoblast, villous stroma and decidua. Our results suggest that immunohistochemistry could be used as a laboratory confirmation method for dengue in pregnant women, especially in endemic areas when embedded material is the only material available.

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Sigma-Aldrich
抗デングウイルス複合体抗体、クローンD3-2H2-9-21, clone D3-2H2-9-21, Chemicon®, from mouse
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