T6515

コレシストキニンフラグメント30-33アミド

≥95% (HPLC)

• 別名: Trp-Met-Asp-Pheアミド, ガストリンテトラペプチド, テトラガストリン 塩酸塩
• 実験式（ヒル表記法）: C₂₉H₃₆N₆O₆S
• CAS番号: 1947-37-1
• 分子量: 596.70
• MDL番号: MFCD00076492
• UNSPSCコード: 12352202
• PubChem Substance ID: 24900382
• NACRES: NA.32

特性

• アッセイ: ≥95% (HPLC)
• 形状: powder
• 分子量: 59670 g/mol
• テクニック: toxicology assay: suitable
• 溶解性: DMF: 20 mg/mL, clear, colorless to yellow
• 適合性: suitable for molecular biology
• UniProtアクセッション番号: P06307; P30553
• 保管温度: −20°C
• SMILES記法: CSCC[C@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc3ccccc3)C(N)=O
• InChI: 1S/C29H36N6O6S/c1-42-12-11-22(33-27(39)20(30)14-18-16-32-21-10-6-5-9-19(18)21)28(40)35-24(15-25(36)37)29(41)34-23(26(31)38)13-17-7-3-2-4-8-17/h2-10,16,20,22-24,32H,11-15,30H2,1H3,(H2,31,38)(H,33,39)(H,34,41)(H,35,40)(H,36,37)/t20-,22-,23-,24-/m0/s1
• InChI Key: RGYLYUZOGHTBRF-BIHRQFPBSA-N
• 遺伝子情報: human ... CCK(885) ; rat ... Cckbr(25706)

詳細

Amino Acid Sequence

Trp-Met-Asp-Phe-NH2

詳細

Research area: Neuroscience

Several biologically active fragments of the neuropeptide cholecystokinin (CCK) are present in the brain, where they interact with CCK-A and CCK-B receptors. Among these fragments, CCK-4 is notably abundant in the cortical and limbic brain structures. CCK-4, a bioactive form of cholecystokinin, is a peptide hormone that regulates food intake by binding to CCK receptors in the gut and brain.

アプリケーション

Cholecystokinin Fragment 30-33 Amide can be used for inactivating the CCK8 antiserum. The product can also be used as an antigen utilized in absorption control for testing the specificity of antisera.Cholecystokinin Fragment 30-33 Amide has been used to induce anxiolytic- and antidepressant-like effects and study the role of neuropeptide Y, in mice.

生物化学的／生理学的作用

Cholecystokinin Fragment 30-33 Amide also referred to as CCK-4 or Trp-Met-Asp-Phe amide is a peptide fragment derived from peptide hormone cholecystokinin. CCK-4 is a panicogenic agent that induces panic attacks in humans. This property of the compound can be used in scientific research for testing new anxiolytic drugs.CCK-4 acts selectively through CCK-B receptors and is recognized for its role in regulating emotional behaviors. Studies on CCK knock-down mice have indicated anxiolytic- and antidepressant-like effects.

包装

底の開いたガラス瓶内容物は内部に挿入され接着された円錐部に入っています。

調製ノート

Cholecystokinin Fragment 30-33 Amide dissolves in Dimethylformamide at 20 mg/ml to yield a clear, colorless to yellow solution.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, type N95 (US)