T3455

テラメプロコル

≥98% (HPLC)

• 別名: 2,3-ジメチル-1,4-ビス-(3,4-ジメトキシフェニル)ブタン, EM-1421, M4N, TMNDGA, rel-4-[(2R,3S)-4-(3,4-ジメトキシフェニル)-2,3-ジメチルブチル]-1,2-ジメトキシベンゼン, テトラ-O-メチル-NDGA, テトラ-O-メチルノルジヒドログアヤレト酸, テトラメチルNDGA, テトラメチルノルジヒドログアヤレト酸
• 実験式（ヒル表記法）: C₂₂H₃₀O₄
• CAS番号: 24150-24-1
• 分子量: 358.47
• MDL番号: MFCD11113155
• UNSPSCコード: 12352200
• PubChem Substance ID: 329826768
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: powder
• 色: white to off-white
• 溶解性: DMSO: ≥10 mg/mL
• 保管温度: −20°C
• SMILES記法: COc1ccc(C[C@H](C)[C@H](C)Cc2ccc(OC)c(OC)c2)cc1OC
• InChI: 1S/C22H30O4/c1-15(11-17-7-9-19(23-3)21(13-17)25-5)16(2)12-18-8-10-20(24-4)22(14-18)26-6/h7-10,13-16H,11-12H2,1-6H3/t15-,16+
• InChI Key: ORQFDHFZSMXRLM-IYBDPMFKSA-N

詳細

生物化学的／生理学的作用

Terameprocol is a synthetic derivative of NDGA, a non-selective lipoxygenase inhibitor. It inhibits Sp1 transcription factor binding at the HIV long terminal repeat promoter and at the α-ICP4 promoter, a gene essential for HSV replication, with IC50 values of 11 and 43.5 μM respectively. TMNDGA induces growth arrest and apoptosis by suppressing Sp1-dependent Cdc2 and survivin gene expression giving rise to its antitumorigenic activity. The in vivo growth of xenografts in numerous human tumor types was suppressed upon treatment with TMNDGA It also inhibits the growth of murine and human melanomas and human colon cancer in vivo without causing other tissue toxicity.

Terameprocol is known to reduce angiogenesis¹.

調製ノート

Terameprocol is soluble in DMSO at a concentration that is greater than or equal to 10 mg/ml.

安全性情報

• ピクトグラム: GHS09
• シグナルワード: Warning
• 危険有害性情報: H410
• 注意書き: P273 - P391 - P501
• 危険有害性の分類: Aquatic Acute 1 - Aquatic Chronic 1
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable