SRP8043

APRIL, Soluble mouse

recombinant, expressed in HEK 293 cells, FLAG^® tagged, >95% (SDS-PAGE)

• 別名: TNFSF10
• UNSPSCコード: 12352200
• NACRES: NA.32

特性

• 由来生物: mouse
• リコンビナント: expressed in HEK 293 cells
• タグ: FLAG^® tagged
• アッセイ: >95% (SDS-PAGE)
• 形状: lyophilized
• 分子量: ~34 kDa by SDS-PAGE
• 包装: pkg of 10 μg
• 保管条件: avoid repeated freeze/thaw cycles
• 不純物: <0.02 EU/μg endotoxin, tested
• 色: white
• UniProtアクセッション番号: Q9D777
• 輸送温度: wet ice
• 保管温度: −20°C
• 遺伝子情報: mouse ... Tnfsf13(69583)

詳細

詳細

APRIL is a cytokine that belongs to the TNF superfamily and binds to TACI and BCMA. It is implicated in the regulation of tumor cell growth, is involved in monocyte/macrophage-mediated immunological processes and functions as an important survival factor for plasmablasts and bone marrow plasma cells. APRIL is a high activity construct in which two trimeric APRIL ligands are artificially linked via the collagen domain of ACRP30. This construct very effectively stimulates proliferation B cell. A basic amino acid sequence (QKQKKQ) close to the N-terminus of APRIL is required for binding to negatively charged sulfated glycosaminoglycan side chains of proteoglycans. Proteoglycans mediate binding of APRIL to tumor cells as well as primary lymphoid cells.

物理的形状

凍結乾燥品(PBS)。

再構成

Reconstitute with 100 μL deionized water.

その他情報

The extracellular domain of mouse APRIL (aa 88-232) is fused at the N-terminus to mouse ACRP30headless (aa 18-110) and a FLAG^®-tag.

法的情報

FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable