SRP8003

Clusterin (nuclear form) mouse

>90% (SDS-PAGE), recombinant, expressed in E. coli, His tagged, liquid

• 別名: CLI
• UNSPSCコード: 12352202
• NACRES: NA.32

特性

• product name: Clusterin (nuclear form) mouse, recombinant, expressed in E. coli, His tagged, >90% (SDS-PAGE)
• 由来生物: mouse
• リコンビナント: expressed in E. coli
• タグ: His tagged
• アッセイ: >90% (SDS-PAGE)
• 形状: liquid
• 分子量: ~45 kDa by SDS-PAGE
• 包装: pkg of 50 μg
• 保管条件: avoid repeated freeze/thaw cycles
• 濃度: ≥0.2 mg/mL
• 不純物: <1 EU/μg endotoxin, tested
• 色: clear
• UniProtアクセッション番号: Q06890
• 輸送温度: wet ice
• 保管温度: −20°C
• 遺伝子情報: mouse ... Clu(12759)

詳細

詳細

Clusterin is expressed in all tissues. However, it is strongly expressed in the central nervous system and plasma. Clusterin mainly protects against heat and other stress. It is also referred as chaperone protein and stress-inducible biomarker. Clusterin exists in two isoforms, one is a secretory form and other is a nuclear form. The secreted form of the protein is a 80kDa disulfide-linked heterodimer of α and β subunits (produced by internal cleavage). The alternatively spliced inactive cytosolic form is changed to a truncated mature nuclear isoform via ionizing irradiation.

生物化学的／生理学的作用

Clusterin is involved in tissue remodeling, cell death, lipid transport, complement-associated cell lysis, cancer and neurological damage. It is strongly expressed in Alzheimer′s and treatment-resistant cancer. High levels of clusterin are observed in ischemic heart disease and diabetic conditions. It also protects kidney from fibrosis. Nuclear form of clusterin works as a pro-death signal, and suppresses cell growth and survival. The secreted form of clusterin has extracellular chaperone and anti-apoptotic activities.

物理的形状

Solution in 55 mM TRIS-HCl, pH 8.2, containing 150 mM NaCl.

その他情報

Mouse nuclear clusterin (aa 22-448) is fused at the C-terminus to a His-tag.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable