SRP7783

MMP-3 ヒト

recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)

• 別名: EC 3, ストロメライシン-1, マトリックスメタロプロテアーゼ-3
• CAS番号: 79955-99-0
• MDL番号: MFCD00282364
• UNSPSCコード: 12352202
• NACRES: NA.32

特性

• 由来生物: human
• リコンビナント: expressed in E. coli
• アッセイ: ≥95% (HPLC); ≥95% (SDS-PAGE)
• フォーム: lyophilized
• 分子量: ~19.5 kDa
• 包装: pkg of 10 μg
• テクニック: western blot (chemiluminescent): suitable
• 不純物: endotoxin, tested
• NCBIアクセッション番号: P08254
• 輸送温度: wet ice
• 保管温度: −20°C
• 遺伝子情報: human ... MMP3(4314)

詳細

詳細

Active MMP-3 catalytic domain from human cDNA, expressed in E. coli and purified using proprietary technologies. The active MMP-3 is very useful in studying enzyme kinetics, cleave target substrates, and screen for inhibitors.

The gene JE is an early growth response gene that was first identified in mouse 3T3 cells. The gene is mapped to mouse chromosome 11. It encodes a member of the CC subfamily, the members of which contain characteristic two adjacent cysteine residues.

アプリケーション

MCP-1 has been used to induce chemotaxis in mice macrophages.

MMP-3 human has been used to develop a simple and sensitive electrogenerated chemiluminescence (electrochemiluminescence (ECL)) peptide-based bioassay for the detection of matrix metalloproteinases releasing from living cells.

生物化学的／生理学的作用

Matrix metallopeptidase 3 (MMP3) has a broad substrate specificity and is capable of degrading fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. It participates in wound repair, progression of atherosclerosis, tissue remodeling and tumor initiation. MMP3 variants can be associated with hypertrophy of interventricular septum or hypertrophic cardiomyopathy.

The gene JE, also referred to as MCP-1 (monocyte chemoattractant protein-1), encodes a secreted chemokine that functions as a chemoattractant for monocytes and may activate their anti-tumor properties. This protein may serve as a potential therapeutic anticancer agent.

物理的形状

凍結乾燥品。

再構成

バイアルは、開封前に遠心してください。凍結融解の繰り返しは避けてください。

Reconstitute in sterile PBS to a concentration of 0.1-1.0 mg/mL. This solution can then be diluted into other aqueous buffers.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable