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由来生物
human
リコンビナント
expressed in HEK 293 cells
タグ
6-His tagged (C-terminus)
アッセイ
≥95% (SDS-PAGE)
形状
lyophilized
分子量
calculated mol wt 35.8 kDa
observed mol wt 50-65 kDa (DTT-reduced. Protein migrates due to glycosylation. Asp 35 is the predicted N-terminal.)
包装
pkg of 10 μg
pkg of 50 μg
UniProtアクセッション番号
輸送温度
wet ice
保管温度
−20°C
遺伝子情報
human ... CD55(1604)
詳細
CD55 (complement decay-accelerating factor), also known as DAF or decay accelerating factor, is a member of the RCA (regulators of complement activation) family characterized by four to 30 SCRs (short consensus repeats) in their plasma-exposed regions. CD55 /DAF is a 70 kDa membrane protein that regulates the complement system on the cell surface. This glycoprotein is broadly distributed among hematopoietic and non-hematopoietic cells.
生物化学的／生理学的作用
CD55 (complement decay-accelerating factor) prevents the assembly of the C3bBb complex (the C3-convertase of the alternative pathway) or accelerates the disassembly of preformed convertase, thus blocking the formation of the membrane attack complex. It is a determinant for the Cromer blood group system. CD55 is known to bind CD97 via the first short consensus repeats (SCR). It also binds physiologically generated C3 convertases with its second and third SCRs. Binding results in an accelerated “decay”, or dissociation of active C3 convertases, thus blocking the development of C′ attack complexes on non-foreign cells. Finally, viruses and bacteria are also known to utilize multiple SCR sites for infection.
物理的形状
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.
再構成
Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
SRP6437-50UG:
SRP6437-10UG:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
An understanding of intervertebral disc development, maturation and cell phenotype provides clues to direct cell-based tissue regeneration therapies for disc degeneration.
Rodrigues-Pinto R, et al.
European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 23(9), 1803-1814 (2014)
Membrane complement regulatory proteins.
Kim D D and Song W C
Clinical Immunology (Orlando, Fla.), 118(2-3), 127-136 (2006)
Structure of complement fragment C3b?factor H and implications for host protection by complement regulators.
Wu J, et al.
Nature Immunology, 10(7), 728-728 (2009)
Hantavirus causing hemorrhagic fever with renal syndrome enters from the apical surface and requires decay-accelerating factor (DAF/CD55).
Krautkramer E and Zeier M
Journal of Virology, 82(9), 4257-4264 (2008)
Molecular basis of reduced or absent expression of decay-accelerating factor in Cromer blood group phenotypes.
Lublin D M, et al.
Blood, 84(4), 1276-1282 (1994)
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