由来生物
rat
リコンビナント
expressed in E. coli
アッセイ
≥95% (SDS-PAGE)
形状
lyophilized
分子量
~11.9 kDa
包装
pkg of 25 μg
不純物
endotoxin, tested
NCBIアクセッション番号
UniProtアクセッション番号
輸送温度
wet ice
保管温度
−20°C
遺伝子情報
rat ... Retn(246250)
詳細
Resistin is a new member to of the family of adipocyte-secreted proteins. The biological functions of resistin, as well as its molecular target, are largely unknown. Whether it promotes or antagonizes insulin action is still unclear. Recombinant rat Resistin is an 11.9 kDa protein consisting of 94 amino acid residues and 16 additional amino acids residues-His Tag.
Resistin is an adipocytokine secreted by fat tissues and is localized to pancreatic α-cells in rat.
Resistin is an adipocytokine secreted by fat tissues and is localized to pancreatic α-cells in rat.
アプリケーション
Resistin from rat has been used to study the effect of resistin on gonadotropins and local ovarian hormone-induced steroidogenesis.
生物化学的／生理学的作用
Resistin mediates energy homeostasis and inflammation process. Upregulation of resistin is observed in obesity. It is also known to increase blood glucose level and might promote insulin resistance. Thus, it might influence type 2 diabetes. Resistin might be linked to insulin resistance mediated myocardial infarction (MI). In rats, overexpression of resistin is observed in myocardial infarction and cardiac dysfunction.
物理的形状
凍結乾燥品(20 mM Tris, pH 8.0)。
再構成
バイアルは、開封前に遠心してください。凍結融解の繰り返しは避けてください。
Reconstitute in water to a concentration of 0.1-1.0 mg/mL. This solution can then be diluted into other aqueous buffers.
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
SRP4561-25UG:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Resistin aggravates the expression of proinflammatory cytokines in cerulein-stimulated AR42J pancreatic acinar cells
Jiang CY and Wang W
Molecular Medicine Reports, 15(1), 502-506 (2017)
Sitagliptin decreases ventricular arrhythmias by attenuated glucose-dependent insulinotropic polypeptide (GIP)-dependent resistin signaling in infarcted rats
Lee TM, et al.
Bioscience Reports, BSR20150139-BSR20150139 (2016)
Resistin is produced by rat pancreatic islets and regulates insulin and glucagon in vitro secretion
Sassek M, et al.
Islets, 8(6), 177-185 (2016)
Regulatory role of gonadotropins and local factors produced by ovarian follicles on in vitro resistin expression and action on porcine follicular steroidogenesis
Rak A, et al.
Biology of Reproduction, 92(6), 142-141 (2015)
Maha M Sabry et al.
Archives of physiology and biochemistry, 126(5), 389-398 (2019-01-08)
Obesity and atherosclerosis are inflammatory states involving variable metabolic signals. The adipokine resistin is implicated in adipose tissue dysfunction and is modulated by PPARγ. In this study, resistin and PPARγ role is investigated in the development of CVS disease. Forty-eight
資料
Lipid Induced Insulin Resistance
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