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由来生物
human
リコンビナント
expressed in CHO cells
アッセイ
≥95% (HPLC)
≥95% (SDS-PAGE)
形状
lyophilized
分子量
80.0-90.0 kDa
包装
pkg of 10 μg
不純物
<0.1 EU/μg endotoxin, tested
色
white
UniProtアクセッション番号
輸送温度
wet ice
保管温度
−20°C
遺伝子情報
human ... AOC3(8639)
詳細
VAP-1 is a type II membrane cell adhesion protein belonging to the copper/topaquinone oxidase family. Recombinant VAP-1 is a mixture of monomeric and disulfide linked homodimeric forms of a 737 amino acid polypeptide corresponding to amino acids 27 to 763 of the VAP-1 precursor. The gene AOC3 (amine oxidase, copper containing 3) encodes a 170kDa homodimeric sialylated glycoprotein, VAP-1 (vascular adhesion protein-1), that is abundantly expressed in high endothelial venules (HEV) of peripheral lymph nodes. It is expressed in capillaries of non-lymphatic human tissues, such as kidney and heart. It is also expressed on on adipocytes, dendritic cells and smooth muscle cells.
生物化学的／生理学的作用
The protein VAP-1 (vascular adhesion protein-1) belongs to the group of semicarbazide sensitive amine oxidases (SSAO) that catalyze the formation of reactive oxygen species. It is a unique adhesion molecule that participates in inflammatory leukocyte recruitment in blood vessels. It functions in leukocyte extravasation to inflamed tissues. In the human eye, it has been associated with ocular inflammatory diseases, such as uveitis, age-related macular degeneration, and diabetic retinopathy. Its expression has been observed to be altered in several diseases, such as rheumatoid arthritis, diabetes, and atherosclerosis.
物理的形状
凍結乾燥品(10 mMリン酸ナトリウム、pH 7.8)。
再構成
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
保管分類コード
10 - Combustible liquids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
SRP3295-1MG:
SRP3295-10UG:
SRP3295-100UG:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
A J Gearing et al.
Immunology today, 14(10), 506-512 (1993-10-01)
The demonstration of soluble isoforms of adhesion molecules has added a layer of complexity of our understanding of lymphoid-endothelial cell interactions. This is especially true in the light of observations which show levels of these isoforms to be raised during
VAP-1-mediated M2 macrophage infiltration underlies IL-1?- but not VEGF-A-induced lymph- and angiogenesis.
Nakao S
The American Journal of Pathology, 178, 1913-1921 (2011)
Lama Almulki et al.
Experimental eye research, 90(1), 26-32 (2009-09-19)
Recently we showed a critical role for Vascular Adhesion Protein-1 (VAP-1) in rodents during acute ocular inflammation, angiogenesis, and diabetic retinal leukostasis. However, the expression of VAP-1 in the human eye is unknown. VAP-1 localization was therefore investigated by immunohistochemistry.
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