SML3564

ML382

≥98% (HPLC)

• 別名: VU0485891, 2-(Cyclopropanesulfonamido)-N-(2-ethoxyphenyl)benzamide
• 実験式（ヒル表記法）: C₁₈H₂₀N₂O₄S
• CAS番号: 1646499-97-9
• 分子量: 360.43
• MDL番号: MFCD30182354
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: powder
• 色: white to beige
• 溶解性: DMSO: 2 mg/mL, clear
• 保管温度: 2-8°C
• SMILES記法: O=C(C1=C(C=CC=C1)NS(C2CC2)(=O)=O)NC3=C(C=CC=C3)OCC

詳細

生物化学的／生理学的作用

ML382 is a positive allosteric modulator of Mas-related G-protein-coupled receptor X1 (MrgprX1, MrgX1, SNSR4), a G-protein coupled receptor (GPCR) selectively expressed in dorsal root ganglion (DRG) neurons. MrgX1 is believed to be a functional ortholog of mouse MrgC11, which has been shown to be involved in itch and pain. ML382 is selective for MrgX1 over MrgX2, MrgC11 and a panel of 68 other GPCRs, ion channels and transporters, with an EC50 value of 190 nm with an Emax value of 148% in the presence of the known ligand BAM8-22.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable