SML1726

MSAB

≥95% (HPLC)

• 別名: 3-[[(4-Methylphenyl)sulfonyl]amino]-benzoic acid methyl ester, Methyl 3-{[(4-methylphenyl)sulfonyl]amino}benzoate, WI-21
• 実験式（ヒル表記法）: C₁₅H₁₅NO₄S
• CAS番号: 173436-66-3
• 分子量: 305.35
• UNSPSCコード: 12352200
• PubChem Substance ID: 329826041

特性

• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• 形状: powder
• 色: off-white to purple
• 溶解性: DMSO: 25 mg/mL, clear
• 保管温度: 2-8°C
• SMILES記法: CC1=CC=C(S(NC2=CC(C(OC)=O)=CC=C2)(=O)=O)C=C1

詳細

生物化学的／生理学的作用

A cell-permeable compound that targets β-catenin via direct affinity interaction within the C-terminal two thirds (a.a. 301-670) of the Armadillo repeat region (a.a. 136–686), inducing β-catenin ubiquitination and proteasomal degradation (Eff. conc. 1.25-5 μM in DLD-1, SW480 and LS174T cultures). MSAB selectively inhibits against Wnt sginaling-dependent proliferation of cancer cells (IC50 <6 μM), while exhibiting little efficacy in Wnt-independent cultures (<10% inhibition at 10 μM). Likewise, daily intraperitoneal injection (10-20 mg/kg/day) is efficacious in suppressing the expansion of established tumors from HCT116, HT115, and H23 xenografts in mice, while exhibiting little efficacy against the Wnt-independent H460 tumor growth.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable