SML1529

Erdosteine

≥98% (HPLC), powder, mucolytic agent

• 別名: ({2-Oxo-2-[(2-oxotetrahydro-3-thienyl)amino]ethyl}sulfanyl)acetic acid, 2-[[2-Oxo-2-[(tetrahydro-2-oxo-3-thienyl)amino]ethyl]thio]acetic acid
• 実験式（ヒル表記法）: C₈H₁₁NO₄S₂
• CAS番号: 84611-23-4
• 分子量: 249.31
• MDL番号: MFCD00867664
• UNSPSCコード: 12352200
• PubChem Substance ID: 329825946
• NACRES: NA.77

特性

• product name: Erdosteine, ≥98% (HPLC)
• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: powder
• 色: white to beige
• 溶解性: DMSO: 20 mg/mL, clear
• 保管温度: 2-8°C
• InChI: 1S/C8H11NO4S2/c10-6(3-14-4-7(11)12)9-5-1-2-15-8(5)13/h5H,1-4H2,(H,9,10)(H,11,12)
• InChI Key: QGFORSXNKQLDNO-UHFFFAOYSA-N

詳細

詳細

Erdosteine is a derivative of thiol, and is used in the treatment of chronic obstructive bronchitis, including acute infective exacerbation of chronic bronchitis.It consists of two blocked sulfhydryl groups, which are released following first-pass metabolism.

アプリケーション

Erdosteine has been used as a mucolytic to study its protective effects on interleukin-1β-stimulated inflammation in rat chondrocytes in osteoarthritis models.

生物化学的／生理学的作用

Erdosteine is a mucolytic drug with expectorant and antitussive effects. Erdosteine is quickly metabolized in vivo to free thiols which act as free radical scavengers. Erdosteine has also been shown to have antioxidant activity through the activation of Nrf2-dependent antioxidant genes and inhibition of pro-inflammatory cytokines.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H302
• 注意書き: P264 - P270 - P301 + P312 - P501
• 危険有害性の分類: Acute Tox. 4 Oral
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable