SML1317

XAP044

≥98% (HPLC)

• 別名: 7-Hydroxy-3-(4-iodophenoxy)-4H-chromen-4-one, XAP 044
• 実験式（ヒル表記法）: C₁₅H₉IO₄
• CAS番号: 196928-50-4
• 分子量: 380.13
• MDL番号: MFCD00525548
• UNSPSCコード: 12352200
• PubChem Substance ID: 329825781
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 保管条件: protect from light
• 色: white to beige
• 溶解性: DMSO: 20 mg/mL, clear
• 保管温度: 2-8°C
• SMILES記法: O=C1C(OC2=CC=C(I)C=C2)=COC3=C1C=CC(O)=C3
• InChI: 1S/C15H9IO4/c16-9-1-4-11(5-2-9)20-14-8-19-13-7-10(17)3-6-12(13)15(14)18/h1-8,17H
• InChI Key: XXZKJJYWINSUMJ-UHFFFAOYSA-N

詳細

生物化学的／生理学的作用

XAP044 is a brain penetrant, potent and selective mGlu7 (metabotropic glutamate receptor subtype 7) antagonist that inhibits lateral amygdala long-term potentiation (LTP) in brain slices from wild type mice. XAP044 binds to a pocket localized in mGlu7′s extracellular Venus flytrap domain (VFTD) close to the binding site of the orthosteric agonist L-glutamate. XAP044 exhibits a wide-spectrum anti-stress, antidepressant- and anxiolytic-like efficacy in rodent behavioral model.

その他情報

Light sensitive. This compound has Iodine and should be kept in the dark.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable