SML1213

A66

≥98% (HPLC)

• 別名: (2S)-N1-[2-(1,1-Dimethylethyl)-4′-methyl[4,5′-bithiazol]-2′-yl]-1,2-pyrrolidinedicarboxamide
• 実験式（ヒル表記法）: C₁₇H₂₃N₅O₂S₂
• CAS番号: 1166227-08-2
• 分子量: 393.53
• MDL番号: MFCD22378485
• UNSPSCコード: 12352200
• PubChem Substance ID: 329825723
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 色: white to beige
• 溶解性: DMSO: 20 mg/mL, clear
• 保管温度: −20°C
• SMILES記法: O=C(N1[C@H](C(N)=O)CCC1)NC2=NC(C)=C(C3=CSC(C(C)(C)C)=N3)S2
• InChI: 1S/C17H23N5O2S2/c1-9-12(10-8-25-14(20-10)17(2,3)4)26-15(19-9)21-16(24)22-7-5-6-11(22)13(18)23/h8,11H,5-7H2,1-4H3,(H2,18,23)(H,19,21,24)/t11-/m0/s1
• InChI Key: HBPXWEPKNBHKAX-NSHDSACASA-N

詳細

生物化学的／生理学的作用

A66 is a potent and highly selective inhibitor of the phosphoinositide 3-kinase (PI3K) catalytic subunit p110α with an IC₅₀ of 32 nM and >100 fold selectivity for p110α over other class-I PI3K isoforms.

A66 is a potent and highly selective inhibitor of the phosphoinositide 3-kinase (PI3K) catalytic subunit p110α.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable