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Merck

SML1124

Sigma-Aldrich

CPCCOEt

≥98% (HPLC)

別名:

7-ヒドロキシイミノシクロプロパン[b]クロメン-1α-カルボン酸エチルエステル

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About This Item

実験式(ヒル表記法):
C13H13NO4
CAS番号:
分子量:
247.25
MDL番号:
UNSPSCコード:
12352200
PubChem Substance ID:
NACRES:
NA.77

品質水準

アッセイ

≥98% (HPLC)

フォーム

powder

保管条件

desiccated

white to beige

溶解性

DMSO: 20 mg/mL, clear

保管温度

2-8°C

SMILES記法

O=C(OCC)C(C1)(OC2=C/3C=CC=C2)C1C3=N/O

InChI

1S/C13H13NO4/c1-2-17-12(15)13-7-9(13)11(14-16)8-5-3-4-6-10(8)18-13/h3-6,9,16H,2,7H2,1H3/b14-11-

InChI Key

FXCTZFMSAHZQTR-KAMYIIQDSA-N

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生物化学的/生理学的作用

mGluR1 代謝型グルタミン酸レセプタ-に対する、強力かつ選択的、非競合的アンタゴニストです。
CPCCOEt is a selective non-competitive metabotropic glutamate receptor mGluR1 antagonist.

特徴および利点

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

保管分類コード

11 - Combustible Solids

WGK

WGK 3

引火点(°F)

Not applicable

引火点(℃)

Not applicable


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Bo Liu et al.
Brain research, 1704, 241-248 (2018-10-23)
Glioma is a primary brain tumor with high frequency and dismal prognosis. As there is no permanent cure available, identifying new therapy or mediator to augment the effectiveness of existing therapy is urgently needed. In the current study we tested
Carrie Bowman Dalley et al.
The Journal of pharmacology and experimental therapeutics, 367(1), 59-70 (2018-07-29)
Glioma refers to malignant central nervous system tumors that have histologic characteristics in common with glial cells. The most prevalent type, glioblastoma multiforme, is associated with a poor prognosis and few treatment options. On the basis of reports of aberrant
Valerie L Hedges et al.
Endocrinology, 159(3), 1328-1338 (2018-01-31)
Estrogens affect cerebellar activity and cerebellum-based behaviors. Within the adult rodent cerebellum, the best-characterized action of estradiol is to enhance glutamatergic signaling. However, the mechanisms by which estradiol promotes glutamatergic neurotransmission remain unknown. Within the mouse cerebellum, we found that
Zhanlei Ye et al.
The Journal of physiology, 595(11), 3483-3495 (2017-02-18)
Spontaneous activity of the sensory inner hair cells shapes maturation of the developing ascending (afferent) auditory system before hearing begins. Just before the onset of hearing, descending (efferent) input from cholinergic neurons originating in the brainstem inhibit inner hair cell
Zhiwen Zeng et al.
Oncotarget, 8(39), 65313-65328 (2017-10-17)
Impairment of insulin-like growth factor I (IGF-I) signaling plays an important role in the development of neurodegeneration. In the present study, we investigated the effect of H

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