SML0959

Bis-1,4-(4-methoxybenzenesulfonamidyl)naphthalene

≥98% (HPLC)

• 別名: Compound 16, N,N′-(Naphthalene-1,4-diyl)bis(4-methoxybenzenesulfonamide)
• 実験式（ヒル表記法）: C₂₄H₂₂N₂O₆S₂
• CAS番号: 321694-20-6
• 分子量: 498.57
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: powder
• 色: , white to light yellow to light gray
• 溶解性: DMSO: 20 mg/mL, clear
• 保管温度: 2-8°C

詳細

生物化学的／生理学的作用

Bis-1,4-(4-methoxybenzenesulfonamidyl)naphthalene is a non-covalent inhibitor of the interaction between Kelch-like ECH-associated protein 1 (Keap1) and nuclear factor erythroid 2-related factor 2 (Nrf2). The Keap1–Nrf2 protein–protein interaction is considered a critical point of the Keap1–Nrf2–ARE (antioxidant response elements) system that protects cells from oxidative stress. Bis-1,4-(4-methoxybenzenesulfonamidyl)naphthalene prevents Keap1 repression of Nrf2 activation, allowing Nrf2 to initiate antioxidant response element (ARE) to protect the cell. Bis-1,4-(4-methoxybenzenesulfonamidyl)naphthalene has an IC₅₀ of 2.7 micromolar and specifically binds to the Keap1 Kelch-DC domain.

特徴および利点

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安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable