SML0848

LM22A-4

≥98% (HPLC)

• 別名: N1,N3,N5-Tris(2-hydroxyethyl)-1,3,5-benzenetricarboxamide
• 実験式（ヒル表記法）: C₁₅H₂₁N₃O₆
• CAS番号: 37988-18-4
• 分子量: 339.34
• UNSPSCコード: 51111800
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 色: white to beige
• 溶解性: H₂O: 2 mg/mL, clear (warmed)
• 保管温度: 2-8°C
• SMILES記法: N(CCO)C(=O)c1cc(cc(c1)C(=O)NCCO)C(=O)NCCO
• InChI: 1S/C15H21N3O6/c19-4-1-16-13(22)10-7-11(14(23)17-2-5-20)9-12(8-10)15(24)18-3-6-21/h7-9,19-21H,1-6H2,(H,16,22)(H,17,23)(H,18,24)
• InChI Key: RGWJKANXFYJKHN-UHFFFAOYSA-N

詳細

アプリケーション

LM22A-4 has been used as a component of dissociation medium for mouse embryonic stem cells (mESC) and human embryonic stem (hESC) aggregates.

生物化学的／生理学的作用

LM22A-4 is a non-peptide and shares similarity with brain-derived neurotrophic factor (BDNF), especially in the loop2 region. It improves oligodendroglia density and favors myelin repair. LM22A-4 elevates the expression of protein kinase B (PKB or Akt) and extracellular signal-regulated kinases (ERKs). LM22A-4 elicits neuroprotection in spinal cord injury (SCI) by deregulating the cleaved-caspase-3 and favoring B-cell lymphoma 2(Bcl-2) expression.

LM22A-4 is a partial agonist of TrkB, a brain-derived neurotrophic factor (BDNF) receptor. In binding assays, LM22A-4 displaces BDNF with an IC₅₀ of 47 nM. The compound restores TrkB phosphorylation and respiratory function in a mouse model of Rett syndrome.

LM22A-4 is a partial agonist of TrkB.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable