SML0760

WIKI4

≥98% (HPLC)

• 別名: 2-[3-[[4-(4-Methoxyphenyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]propyl]-1Hbenz[de]isoquinoline-1,3(2H)-dione
• 実験式（ヒル表記法）: C₂₉H₂₃N₅O₃S
• CAS番号: 838818-26-1
• 分子量: 521.59
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 色: white to beige
• 溶解性: DMSO: 10 mg/mL, clear (warmed)
• 保管温度: −20°C
• InChI: 1S/C29H23N5O3S/c1-37-22-11-9-21(10-12-22)34-26(20-13-15-30-16-14-20)31-32-29(34)38-18-4-17-33-27(35)23-7-2-5-19-6-3-8-24(25(19)23)28(33)36/h2-3,5-16H,4,17-18H2,1H3
• InChI Key: RNUXIZKXJOGYQP-UHFFFAOYSA-N

詳細

生物化学的／生理学的作用

WIKI4 is a potent inhibitor of Wnt/β-catenin signaling with an EC₅₀ ~ 75 nM in all cell lines tested including DLD1 colorectal cancer cells, NALM6 B cells, U2OS osteosarcoma cells, and hESCs. WIKI4 inhibits auto-ADP-ribosylation of tankyrase 2 (TNKS2) with an IC₅₀ of 15 nM, preventing the ubiquitination and degradation of axin and thereby antagonizing Wnt signalling.

WIKI4 is a potent inhibitor of Wnt/β-catenin signaling.

特徴および利点

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安全性情報

• 保管分類コード: 13 - Non Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable