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Merck
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安全性情報

SML0453

Sigma-Aldrich

TBPB

≥98% (HPLC)

別名:

1-(1′-(2-Methylbenzyl)-1,4′-bipiperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one

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About This Item

実験式（ヒル表記法）:
C25H32N4O
CAS番号:
634616-95-8
分子量:
404.55
MDL番号:
MFCD22666590
UNSPSCコード:
12352200
PubChem Substance ID:
329824732
NACRES:
NA.77

品質水準

100

アッセイ

≥98% (HPLC)

フォーム

powder

色

white to beige

溶解性

DMSO: 5 mg/mL (clear solution; warmed)

保管温度

2-8°C

SMILES記法

Cc1ccccc1CN2CCC(CC2)N3CCC(CC3)N4C(=O)Nc5ccccc45

InChI

1S/C25H32N4O/c1-19-6-2-3-7-20(19)18-27-14-10-21(11-15-27)28-16-12-22(13-17-28)29-24-9-5-4-8-23(24)26-25(29)30/h2-9,21-22H,10-18H2,1H3,(H,26,30)

InChI Key

CWPKTBMRVATCBL-UHFFFAOYSA-N

生物化学的／生理学的作用

TBPB is a highly selective Muscarinic M1 receptor allosteric agonist.
TBPB is a highly selective Muscarinic M1 receptor allosteric agonist. It activates M1 through an allosteric site rather than the orthosteric acetylcholine binding site, which is likely critical for its selectivity. Muscarinic 1 (M1) receptors are expressed in brain regions responsible for attention and memory, including hippocampus, cortex, and striatum. M1 activation is a proposed mechanism for increasing information processing in disease states, such as Alzheimer′s. M1 agonists are being studied as potential therapeutic agents to treat Alzheimer′s disease and the cognitive and negative symptoms of schizophrenia.

特徴および利点

This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

保管分類コード

11 - Combustible Solids

WGK

WGK 3

引火点(°F)

Not applicable

引火点(℃)

Not applicable

適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

Jan Code

SML0453-BULK:
SML0453-VAR:
SML0453-IP:
SML0453-25MG:
SML0453-5MG:

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試験成績書（COA）

Lot/Batch Number
082M4626V

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文書ライブラリにアクセスする

Hidenori Hashimoto et al.
Scientific reports, 7(1), 17216-17216 (2017-12-10)
Ionic clathrate hydrates can selectively capture small gas molecules such as CO
Ashwini Kumar et al.
Journal of the Formosan Medical Association = Taiwan yi zhi, 115(1), 3-10 (2015-07-30)
Alzheimer's disease (AD) is a neurodegenerative disorder in which the death of brain cells causes memory loss and cognitive decline, i.e., dementia. The disease starts with mild symptoms and gradually becomes severe. AD is one of the leading causes of
Shang-Chi Lin et al.
Scientific reports, 4, 6976-6976 (2014-11-14)
A good diagnostic procedure avoids wasting medical resources, is easy to use, resists contamination, and provides accurate information quickly to allow for rapid follow-up therapies. We developed a novel diagnostic procedure using a "cotton-based diagnostic device" capable of real-time detection
Ya'nan Wang et al.
Polymers, 12(5) (2020-05-30)
Ring-opening copolymerization (ROCOP) is an effective means to prepare functionalized polyester. In this work, a type of selenide-containing polyesters with controllable structure, molecular weight, and molecular weight distribution was successfully prepared by ROCOP of γ-selenobutyrolactone and epoxy compounds. The influence

資料

Acetylcholine Receptors (Muscarinic)

We offers many products related to muscarinic acetylcholine receptors for your research needs.

Acetylcholine Receptors (Muscarinic)

Muscarinic acetylcholine receptors are G protein-coupled receptors (GPCRs) and mediate acetylcholine actions in the CNS and non-nervous tissues. Learn more about acetylcholine receptors and their role in cell signaling.

ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.

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