SML0053

CP-101,606

≥98% (HPLC)

• 別名: トラキソプロジル; (1S,2S)-1-(4-ヒドロキシ-フェニル)-2-(4-ヒドロキシ-4-フェニルピペリジノ)-1-プロパノール; CP-101606
• 実験式（ヒル表記法）: C₂₀H₂₅NO₃
• CAS番号: 134234-12-1
• 分子量: 327.42
• MDL番号: MFCD00926469
• UNSPSCコード: 12352200
• PubChem Substance ID: 329825120
• NACRES: NA.77

特性

• アッセイ: ≥98% (HPLC)
• 形状: powder
• 光学活性: [α]/D +50 to +60° (c=1, MeOH)
• 色: white to tan
• 溶解性: DMSO: ≥35 mg/mL
• 保管温度: 2-8°C
• SMILES記法: C[C@@H]([C@@H](O)c1ccc(O)cc1)N2CCC(O)(CC2)c3ccccc3
• InChI: 1S/C20H25NO3/c1-15(19(23)16-7-9-18(22)10-8-16)21-13-11-20(24,12-14-21)17-5-3-2-4-6-17/h2-10,15,19,22-24H,11-14H2,1H3/t15-,19+/m0/s1
• InChI Key: QEMSVZNTSXPFJA-HNAYVOBHSA-N
• 遺伝子情報: human ... GRIN1(2902) , GRIN2B(2904)

詳細

詳細

CP-101,606 (Traxoprodil) is a substituted 4-phenylpiperidine and is localized in the fore brain neurons.

アプリケーション

CP-101,606 has been used as a N-methyl-D-aspartate (NMDA) receptor antagonist to study its role in recovery of spinal cord injuries.

生物化学的／生理学的作用

トラキソプロジル(CP-101,606)はN-メチル-D-アスパラギン酸(NMDA)受容体の強力な非競合的拮抗薬で、NR2Bサブユニットに選択的に作用します。脳損傷および脳卒中の動物モデルで、神経保護作用をもつことが明らかになっています。

CP-101,606 (Traxoprodil) plays a role in inhibiting glutamate-induced death in rats. It may exhibit therapeutic effects against human ischemia and neurodegenerative disorders. Traxoprodil is metabolized by cytochrome P450 (CYP) 2D6.

特徴および利点

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable