SAE0216

Pepstatin, water soluble

semisynthetic, >=95% pure

• 別名: GKK pepstatyl, Gly-Lys-Lys-pepstatyl, Pepsin inhibitor
• UNSPSCコード: 12352202

特性

• 由来生物: synthetic
• 品質水準: 200
• 形状: powder
• 輸送温度: wet ice
• 保管温度: -10 to -25°C

詳細

詳細

Pepstatin water soluble is a semisynthetic product derived from microbial Pepstatin A by the addition of the tri-peptide Gly-Lys-Lys-OH. Pepstatin water soluble is a novel product that has the same protease inhibition activity as Pepstatin A, but with increased solubility in water and in physiological media. The increased water solubility provides new options for using this inhibitor in aqueous solutions. Pepstatin water soluble was first described by Austen at al,. The published Ki for inhibition of Pepsin activity is the same as Pepstatin A. While Pepstatin A is only sparingly soluble in water or PBS, the water soluble Pepstatin product is soluble in water and PBS at concentration of 60 mg/ml .

アプリケーション

Both Pepstatin A and Water soluble Pepstatin are potent inhibitors of aspartyl proteases. Both of them contain the unusual amino acid statine. Pepstatin A is an inhibitor of acid proteases (aspartyl peptidases). It forms a 1:1 complex with proteases such as pepsin, renin, , cathepsin D , bovine chymosin, and protease B (Aspergillus Niger).4 Solubilized γ-secretase6 and retroviral protease7 are also inhibited by Pepstatin A.

特徴および利点

• Same protease inhibition activity as Pepstatin A
• Icreased solubility in water and in physiological media

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable