SAB5702658

Anti-CHM Antibody, clone 2F7W2, Rabbit Monoclonal

• 別名: CHM, DXS540, GGTA, HSD-32, REP-1, TCD, CHM, Rab escort protein 1
• UNSPSCコード: 12352203

特性

• 由来生物: rabbit
• 品質水準: 100
• 物質: colorless
• クローン: 2F7W2, monoclonal
• 形状: liquid
• 分子量: 101 kDa
• 化学種の反応性: human
• 濃度: 0.40 mg/mL
• テクニック: western blot: 1:500 - 1:2000
• 色: colorless
• アイソタイプ: IgG
• 免疫原配列: MADTLPSEFDVIVIGTGLPESIIAAACSRSGRRVLHVDSRSYYGGNWASFSFSGLLSWLKEYQENSDIVSDSPVWQDQILENEEAIALSRKDKTIQHVEV
• UniProtアクセッション番号: P24386
• 輸送温度: wet ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... CHM(1121)

詳細

詳細

This gene encodes component A of the RAB geranylgeranyl transferase holoenzyme. In the dimeric holoenzyme, this subunit binds unprenylated Rab GTPases and then presents them to the catalytic Rab GGTase subunit for the geranylgeranyl transfer reaction. Rab GTPases need to be geranylgeranyled on either one or two cysteine residues in their C-terminus to localize to the correct intracellular membrane. Mutations in this gene are a cause of choroideremia; also known as tapetochoroidal dystrophy (TCD). This X-linked disease is characterized by progressive dystrophy of the choroid, retinal pigment epithelium and retina. Alternatively spliced transcript variants have been found for this gene.

免疫原

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CHM (P24386).

PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

アプリケーション

WB

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1