SAB5701890

Anti-Phospho-SHC1-Y317 antibody produced in rabbit

• UNSPSCコード: 12352203

特性

• 由来生物: rabbit
• 品質水準: 100
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 形状: liquid
• 化学種の反応性: human
• 濃度: 2.34 mg/mL
• テクニック: western blot: 1:500-1:2000
• UniProtアクセッション番号: P29353
• 輸送温度: wet ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: phosphorylation (pTyr317)
• 遺伝子情報: human ... SHC1(6464)

詳細

詳細

This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

免疫原

A phospho specific peptide corresponding to residues surrounding Y317 of human SHC1.

物理的形状

Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable