SAB4702062

Monoclonal Anti-HLA-E purified produced in mouse

• 別名: HLA class I histocompatibility antigen, MHC class I antigen E, alpha chain E
• UNSPSCコード: 12352203

特性

• 結合体: unconjugated
• 品質水準: 100
• 抗体製品タイプ: primary antibodies
• クローン: MEM-E/02, monoclonal
• フォーム: buffered aqueous solution
• 化学種の反応性: ( Non-human primates), human
• 濃度: 1 mg/ml
• テクニック: immunohistochemistry: suitable; western blot: suitable
• アイソタイプ: IgG1
• UniProtアクセッション番号: P13747
• 保管温度: 2-8°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... HLA-E(3133)

詳細

詳細

HLA-E (human leukocyte antigen E) is a non-classical MHC I antigen, which is important for dialogue with NK cells and their regulation through interaction with CD94/NKG2 receptor. Like other MHC I molecules, transmembrane HLA-E molecule (45 kDa) associates with beta2 microglobulin. Unlike HLA-G, expression of HLA-E molecules is not so restricted, but it has been detected at least at mRNA level in virtually all cells and tissues examined. In peripheral blood, HLA-E protein is expressed at least in all mononuclear cells, but in different quantity (B cells and monocytes more than T cells and NK cells).

特異性

The antibody MEM-E/02 specifically reacts with an extracellular epitope on denaturated heavy chain of human HLA-E. HLA-E belongs to the MHC Class I molecules (MHC Class Ib; nonclassical) and it is expressed on the surface of all human cell types.

免疫原

Recombinant human HLA-E denaturated heavy chain.

物理的形状

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

調製ノート

Purified by protein-A affinity chromatography.

保管および安定性

Store at 2-8°C. Do not freeze.

その他情報

The antibody solution should be gently mixed before use.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable