SAB4702053

Monoclonal Anti-CD7 PE-Cyanine7 produced in mouse

• 別名: GP40, LEU-9, TLA, TP41
• UNSPSCコード: 12352203

特性

• 結合体: PE-Cy7 conjugate
• 品質水準: 100
• 抗体製品タイプ: primary antibodies
• クローン: MEM-186, monoclonal
• フォーム: buffered aqueous solution
• 交差性: human
• テクニック: flow cytometry: suitable
• アイソタイプ: IgG1
• UniProtアクセッション番号: P09564
• 保管温度: 2-8°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... CD7(924)

詳細

詳細

CD7, also known as gp40, is a member of the immunoglobulin superfamily found on T cells, NK cells, thymocytes, hematopoietic progenitors, and monocytes (weakly). CD7 is also expressed on acute lymphocytic leukemia (ALL). CD7 crosslinking induces a calcium flux in T lymphocytes, presumably as a result of cytoplasmic domain association with PI3-kinase. CD7 co-stimulation can induce cytokine secretion and modulate cellular adhesion. A ligand of CD7, epithelial cell secreted protein K12, is produced in thymus to regulate thymocyte signaling and cytokine release. In lung microvascular endothelial cells CD7 serves as an IgM Fc receptor. Expression of CD7 is an important marker used in leukemia diagnostics.

特異性

The antibody MEM-186 reacts with an extracellular epitope of CD7, a 40 kD type I transmembrane glycoprotein expressed on peripheral blood T lymphocytes, NK-cells, hematopoietic progenitors, monocytes (weakly) and also on acute lymphocytic leukemia.

免疫原

Human acute myelogenous leukaemia cell line KG-1.

物理的形状

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

調製ノート

Purified antibody is conjugated with activated tandem dye of R-phycoerythrin-cyanine 7 (PE-Cy7) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

保管および安定性

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

その他情報

The antibody solution should be gently mixed before use.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable