SAB4702008

Monoclonal Anti-CD73 FITC produced in mouse

• 別名: CALJA, E5NT, NT5E, NTE, ecto-5´nucleotidase
• UNSPSCコード: 12352203

特性

• 結合体: FITC conjugate
• 品質水準: 100
• 抗体製品タイプ: primary antibodies
• クローン: AD2, monoclonal
• フォーム: buffered aqueous solution
• 交差性: ( Non-human primates), human
• テクニック: flow cytometry: suitable
• アイソタイプ: IgG1κ
• UniProtアクセッション番号: P21589
• 保管温度: 2-8°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... NT5E(4907)

詳細

詳細

CD73 (ecto-5´-nucleotidase) is a 70 kDa glycoprotein anchored to the extracellular leaflet of the plasma membrane by GPI. This ecto-enzyme catalyzes dephosphorylation of AMP to adenosine. CD73 is expressed in various types of cells, such as epithelial, muscle, and endothelial cells, neutrophils, lymphocytes and fibroblasts. Inflammatory mediators support CD73 expression and its enzymatic activity, leading to the release of adenosine, which modulates inflammation through adenosine receptors. CD73 is expressed in a variety of lymphomas and leukemias, including ALL and CLL, whereas immunodeficient patients usually express low levels of this protein.

特異性

The mouse monoclonal antibody AD2 recognizes CD73, a 70 kDa GPI-anchored 5´-nucleotidase expressed predominantly on the surface of T and B cell subsets, follicular dendritic cells and endothelial cells.

免疫原

pre-B leukemia cells

物理的形状

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

調製ノート

Purified antibody is conjugated with fluorescein isothiocyanate (FITC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

保管および安定性

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

その他情報

The antibody solution should be gently mixed before use.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable