SAB4700423

Monoclonal Anti-CD326 antibody produced in mouse

clone VU-1D9, purified immunoglobulin, buffered aqueous solution

• 別名: 抗EPCAM抗体
• UNSPSCコード: 12352203
• NACRES: NA.41
• 結合体: unconjugated
• application: WB
• クローン: VU-1D9, monoclonal
• 化学種の反応性: human
• citations: 8
• テクニック: western blot: suitable

特性

• 由来生物: mouse
• 品質水準: 100
• 結合体: unconjugated
• 抗体製品の状態: purified immunoglobulin
• 抗体製品タイプ: primary antibodies
• クローン: VU-1D9, monoclonal
• フォーム: buffered aqueous solution
• 化学種の反応性: human
• 濃度: 1 mg/mL
• テクニック: western blot: suitable
• アイソタイプ: IgG1
• NCBIアクセッション番号: NM_002354.2
• UniProtアクセッション番号: P16422
• 輸送温度: wet ice
• 保管温度: 2-8°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... EPCAM(4072)

詳細

詳細

Epithelial cell adhesion molecule (EpCAM) or cluster of differentiation 326 (CD326) is encoded by the 14 kb GA733-2 gene mapped to human chromosome 2p21. Human EpCAM expression is restricted to epithelia of colon, small intestine, lung, kidney, thymus, liver, pancreas, stomach. It is also expressed in several cancers, progenitor and stem cells. CD326 is a transmembrane glycoprotein characterized with an ectodomain, one transmembrane domain, and a 26 residual cytoplasmic domain.

The mouse monoclonal antibody VU-1D9 recognizes an epitope within EGF-like domain I of CD326 / EpCAM, a marker of epithelial lineages. This antibody strongly stains various normal epithelial cells and carcinomas.

免疫原

Small cell lung carcinoma cell line H69

アプリケーション

Suggested working dilution for immunoblotting is 1-4 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.

生物化学的／生理学的作用

Epithelial cell adhesion molecule (EpCAM, CD326) is a transmembrane glycoprotein, involved in several cellular functions, such as epithelial-specific intercellular cell–adhesion, cell signaling, migration, proliferation and differentiation. EpCAM is a dominant surface antigen mapped on human colon carcinoma. It has potential as a diagnostic marker for several carcinomas, including epithelial ovarian cancer (EOC). EpCAM is considered to be a potential target for cancer treatment. EpCAM with the help of components of wnt signal transduction pathway plays a vital role in stem cell signaling.

特徴および利点

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

物理的形状

PBS（pH 7.4、15 mM アジ化ナトリウム含有）

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable