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由来生物
mouse
品質水準
結合体
unconjugated
抗体製品の状態
purified immunoglobulin
抗体製品タイプ
primary antibodies
クローン
MEM-15, monoclonal
形状
buffered aqueous solution
化学種の反応性
human, nonhuman primates
濃度
1 mg/mL
テクニック
flow cytometry: suitable
アイソタイプ
IgG1
NCBIアクセッション番号
UniProtアクセッション番号
輸送温度
wet ice
保管温度
2-8°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... CD14(929)
詳細
CD14 (cluster of differentiation 14) is a myelomonocytic differentiation antigen, encoded by the gene mapped to human chromosome 5q23-31. It is mainly expressed by monocytes, macrophages and activated granulocytes.
免疫原
A crude mixture of human urinary proteins precipitated by ammonium sulphate from the urine of a patient suffering from proteinuria
アプリケーション
The reagent is designed for Flow Cytometry analysis. Suggested working dilution for Flow Cytometry is 4 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.
生物化学的／生理学的作用
CD14 (cluster of differentiation 14) serves as an important receptor of bacterial lipopolysaccharide (LPS). CD14 and LPs complex interacts with toll-like receptor 4 and enhances the expression of inflammatory mediators, including tumor necrosis factor (TNF)- and interleukin (IL)-1, via p38 mitogen-activated protein kinase and nuclear factor-B pathway. Mutation in the gene is associated with the development of myeloid leukemias and generalized chronic periodontitis (GCP).
特徴および利点
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
物理的形状
PBS（pH 7.4、15 mM アジ化ナトリウム含有）
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
SAB4700097-100UG:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Synergistic contribution of CD14 and HLA loci
in the susceptibility to Buerger disease
Chen Z
Human Genetics, 122, 367-372 (2007)
The CD14 monocyte differentiation antigen maps to a region encoding growth factors and receptors.
Goyert SM
Science, 239, 497-500 (1988)
Cytogenetic and molecular delineation of the smallest commonly
deleted region of chromosome 5 in malignant myeloid diseases
Le Beau MM
Proceedings of the National Academy of Sciences of the USA, 90, 5484-5488 (1993)
Dilshi Ishaan et al.
Genetic testing and molecular biomarkers, 21(9), 560-564 (2017-08-23)
The genetic variation in the CD14 rs2569190 promoter region contributes to the susceptibility of developing periodontitis. Since, CD14 gene polymorphism studies among various ethnic populations have produced conflicting results, the present study was designed to unearth the association between the
D P Funda et al.
Infection and immunity, 69(6), 3772-3781 (2001-05-12)
Human endothelial as well as epithelial cells were shown to respond to lipopolysaccharides (LPSs). However, the expression and release of CD14 by these so-called CD14-negative cells have not been studied in detail. We investigated three human intestinal epithelial cell lines
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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