SAB4504517

Anti-phospho-PKR (pThr⁴⁴⁶) antibody produced in rabbit

affinity isolated antibody

• 別名: Anti-DYT33, Anti-EIF2AK1, Anti-LEUDEN, Anti-PKR, Anti-PPP1R83, Anti-PRKR
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 形状: buffered aqueous solution
• 分子量: antigen 62 kDa
• 化学種の反応性: rat, human, mouse
• 濃度: ~1 mg/mL
• テクニック: ELISA: 1:10000; western blot: 1:500-1:1000
• NCBIアクセッション番号: P19525
• UniProtアクセッション番号: P19525
• 輸送温度: wet ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: phosphorylation (pThr446)
• 遺伝子情報: human ... EIF2AK2(5610)

詳細

詳細

EIF2AK2 (eukaryotic translation initiation factor 2α kinase 2) is an intracellular protein, that is also called as RNA-dependent protein kinase (PKR). It belongs to the eIF2αfamily of protein kinases. PKR contains two RNA binding domains and a kinase domain. This gene is located on human chromosome 2p22-p21.

免疫原

The antiserum was produced against synthesized peptide derived from human PKR around the phosphorylation site of Thr446.

Immunogen Range: 413-462

生物化学的／生理学的作用

EIF2AK2 (eukaryotic translation initiation factor 2 α kinase 2) plays a key role in antiviral response promoted by interferons. This gene is involved in stress responses and inflammation pathways. This gene controls the development and multiplication of cells, nutrient signaling and metabolism. EIF2AK2 also participates in several cell regulatory pathways like antiviral activity, growth suppression, transcriptional regulation and apoptosis.

特徴および利点

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物理的形状

ウサギIgGのPBS溶液（Mg2+およびCa2+を含まず）、pH 7.4、150 mM NaCl、0.02％ アジ化ナトリウム、50％ グリセロール

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable