SAB4503993

Anti-phospho-Survivin (pThr³⁴) antibody produced in rabbit

affinity isolated antibody

• UNSPSCコード: 12352203
• NACRES: NA.41
• 結合体: unconjugated
• application: ELISA; WB
• クローン: polyclonal
• 化学種の反応性: rat, human, mouse
• citations: 4
• テクニック: ELISA: 1:1000; western blot: 1:500-1:1000

特性

• 由来生物: rabbit
• 品質水準: 100
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: buffered aqueous solution
• 分子量: antigen 16 kDa
• 化学種の反応性: rat, human, mouse
• 濃度: ~1 mg/mL
• テクニック: ELISA: 1:1000; western blot: 1:500-1:1000
• NCBIアクセッション番号: O15392
• UniProtアクセッション番号: O15392
• 輸送温度: wet ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: phosphorylation (pThr34)
• 遺伝子情報: human ... BIRC5(332)

詳細

詳細

Survivin is also termed as BIRC5 (baculoviral inhibitor of apoptosis repeat-containing 5). It is a multifunctional protein. It belongs to the inhibitor of apoptosis protein (IAP) family. BIRC5 is expressed in fetal tissues and several human malignancies like melanoma. Survivin is located on human chromosome 17q25.

免疫原

The antiserum was produced against synthesized peptide derived from human Survivin around the phosphorylation site of Thr34.

Immunogen Range: 11-60

生物化学的／生理学的作用

Survivin/BIRC5 (baculoviral inhibitor of apoptosis repeat-containing 5) plays a major role in ATL (adult T-cell leukemia/lymphoma) cell viability. It can block apoptosis and induce the multiplication of cell. BIRC5 also plays a major role in the development of cancer.

特徴および利点

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物理的形状

ウサギIgGのPBS溶液（Mg2+およびCa2+を含まず）、pH 7.4、150 mM NaCl、0.02％ アジ化ナトリウム、50％ グリセロール

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable