おすすめの製品
由来生物
rabbit
品質水準
結合体
unconjugated
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
フォーム
buffered aqueous solution
分子量
antigen 48 kDa
化学種の反応性
rat, human, mouse
濃度
~1 mg/mL
テクニック
ELISA: 1:40000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBIアクセッション番号
UniProtアクセッション番号
輸送温度
wet ice
保管温度
−20°C
ターゲットの翻訳後修飾
phosphorylation (pSer422)
遺伝子情報
human ... SGK1(6446)
詳細
The serum- and glucocorticoid-regulated kinase (Sgk1) is a member of the AGC kinase family. It is located on human chromosome 6q23.
免疫原
The antiserum was produced against synthesized peptide derived from human SGK around the phosphorylation site of Ser422.
Immunogen Range: 381-430
Immunogen Range: 381-430
生物化学的/生理学的作用
The serum- and glucocorticoid-regulated kinase (Sgk1) controls ENaC (expressed renal epithelial Na+ channel) by mineralocorticoids. SGK1 controls p27 phosphorylation upon the activation by mTOR-Raptor.
特徴および利点
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
物理的形状
ウサギIgGのPBS溶液(Mg2+およびCa2+を含まず)、pH 7.4、150 mM NaCl、0.02% アジ化ナトリウム、50% グリセロール
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
WGK 1
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
SAB4503834-100UG:
最新バージョンのいずれかを選択してください:
Antioxidants (Basel, Switzerland), 10(10) (2021-10-24)
Anticancer activities of plant polyphenols have been demonstrated in various models of neoplasia. However, evidence obtained in numerous in vitro studies indicates that proliferation arrest and/or killing of cancer cells require quite high micromolar concentrations of polyphenols that are difficult
Definition of disease-risk stratification groups in childhood medulloblastoma using combined clinical, pathologic, and molecular variables
Journal of Clinical Oncology, 29(11), 1400-1407 (2011)
mTOR-raptor binds and activates SGK1 to regulate p27 phosphorylation
Molecular Cell, 30(6), 701-711 (2008)
Impaired renal Na(+) retention in the sgk1-knockout mouse
The Journal of Clinical Investigation, 110(9), 1263-1268 (2002)
Journal of cell science, 135(23) (2022-11-15)
Mammalian (or mechanistic) target of rapamycin complex 2 (mTORC2) is a kinase complex that targets predominantly Akt family proteins, SGK1 and protein kinase C (PKC), and has well-characterized roles in mediating hormone and growth factor effects on a wide array
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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