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由来生物
rabbit
結合体
unconjugated
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
形状
buffered aqueous solution
分子量
antigen 52 kDa
化学種の反応性
human, mouse
濃度
~1 mg/mL
テクニック
ELISA: 1:5000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBIアクセッション番号
UniProtアクセッション番号
輸送温度
wet ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... WAS(7454)
詳細
Anti-WASP Antibody detects endogenous levels of total WASP protein.
WASP (Wiskott-Aldrich syndrome protein) codes for a 65 kDa protein, localized to the cytoplasm. The WASP gene is mapped to human chromosome Xp11.23.
免疫原
The antiserum was produced against synthesized peptide derived from human WASP.
Immunogen Range: 256-305
Immunogen Range: 256-305
生物化学的／生理学的作用
WASP (Wiskott-Aldrich syndrome protein) is regarded as a scaffold protein that integrates cell surface signals to actin cytoskeleton. WASP gene regulates actin polymerization, contributing to T-cell activation and migration. Neural WASP is known to regulate a variety of cellular processes including pathogen infection, vesicle trafficking, invadopodium formation and growth, and neurite extension. Mutation in this gene causes WAS, a X-linked recessive immunodeficiency disorder.
特徴および利点
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
物理的形状
ウサギIgGのPBS溶液（Mg2+およびCa2+を含まず）、pH 7.4、150 mM NaCl、0.02％ アジ化ナトリウム、50％ グリセロール
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
nwg
引火点(°F)
Not applicable
引火点(℃)
Not applicable
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Molecular difference between WASP and N-WASP critical for chemotaxis of T-cells towards SDF-1α
Jain N, et al.
Scientific Reports, 5, 15031-15031 (2015)
Neural Wiskott-Aldrich syndrome protein (nWASP) is implicated in human lung cancer invasion
Frugtniet BA, et al.
BMC Cancer, 17(1), 224-224 (2017)
X-Linked Syndrome of Polyendocrinopathy, Immune Dysfunction, and Diarrhea Maps to Xp11.23-Xq13.3
Bennett CL, et al.
American Journal of Human Genetics, 66(2), 461-468 (2000)
Novel WASP mutation in a patient with Wiskott-Aldrich syndrome: Case report and review of the literature.
Eghbali M, et al.
Allergologia et Immunopathologia, 44(5), 450-454 (2016)
Noah Joseph et al.
FEBS letters, 588(21), 3808-3815 (2014-09-15)
The Nck adapter protein is involved in key cellular functions, such as actin polymerization and reorganization, serving as a molecular bridge between the surface complex essential for foreign antigen recognition, the T-cell antigen receptor (TCR), and the actin machinery. However
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