SAB4503023

Anti-C1S (heavy chain, Cleaved-Arg⁴³⁷) antibody produced in rabbit

affinity isolated antibody

• 別名: C1 esterase, C1S, Complement C1s subcomponent, Complement component 1 subcomponent s
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 形状: buffered aqueous solution
• 分子量: antigen 47 kDa; antigen 76 kDa
• 化学種の反応性: human
• 濃度: ~1 mg/mL
• テクニック: ELISA: 1:20000; western blot: 1:500-1:1000
• NCBIアクセッション番号: P09871
• UniProtアクセッション番号: P09871
• 輸送温度: wet ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: proteolytically cleaved (Arg437)
• 遺伝子情報: human ... C1S(716)

詳細

詳細

Anti-C1S (heavy chain, Cleaved-Arg⁴³⁷ Antibody detects endogenous levels of fragment of activated C1S (heavy chain, Cleaved-Arg⁴³⁷protein.

The C1S (complement C1s) gene is mapped to human chromosome 12p13 and codes for a subcomponent of C1 complex of the classical pathway.

免疫原

The antiserum was produced against synthesized peptide derived from human C1S.

Immunogen Range: 388-437

生物化学的／生理学的作用

Activation of C1s (complement C1s) along with C1r triggers complement cascade. C1s is responsible for the cleavage of complement component C4 and C2, which is necessary for complete activation of complement system. Studies determined that C1s specifically acts on Val or Leu at P(3) and Ala or Gly residues at P(2) positions. The C1S gene is known to be associated lupus nephritis, with low gene expression observed in mice.

特徴および利点

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物理的形状

ウサギIgGのPBS溶液（Mg2+およびCa2+を含まず）、pH 7.4、150 mM NaCl、0.02％ アジ化ナトリウム、50％ グリセロール

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: nwg
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable