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Key Documents

安全性情報

SAB4502010

Sigma-Aldrich

Anti-NNOS antibody produced in rabbit

affinity isolated antibody

別名:

bNOS

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About This Item

MDL番号:
UNSPSCコード:
12352203
NACRES:
NA.41

由来生物

rabbit

結合体

unconjugated

抗体製品の状態

affinity isolated antibody

抗体製品タイプ

primary antibodies

クローン

polyclonal

形状

buffered aqueous solution

分子量

antigen 160 kDa

化学種の反応性

human, mouse, rat

濃度

~1 mg/mL

テクニック

ELISA: 1:1000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000

NCBIアクセッション番号

UniProtアクセッション番号

輸送温度

wet ice

保管温度

−20°C

ターゲットの翻訳後修飾

unmodified

遺伝子情報

human ... NOS1(4842)

詳細

Anti-NNOS antibody detects endogenous levels of total NNOS protein.
The NNOS (nitric oxide synthase 1) gene is mapped to human chromosome 12q24.22. Neuronal nitric oxide synthase is known to be expressed in skeletal muscles, the heart and the brain.

免疫原

The antiserum was produced against synthesized peptide derived from human nNOS.

Immunogen Range: 818-867

アプリケーション

Anti-NNOS antibody produced in rabbit has been used in immunohistochemistry.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)

生物化学的/生理学的作用

NNOS (nitric oxide synthase 1) is responsible for the synthesis of NO (nitric oxide) as well as superoxide. Stress induces the activity of NNOS and generation of NO and results in the formation of nitrogen radicals. Elevation of nitrogen radical leads to intracellular protein damage and also induces impairment to mitochondrial transport chain components. This generally results in cellular energy deficiency. NNOS is known to regulate vasodilation in the forearm, in response to stress. Neuronal nitric oxide synthase normally functions to control the basal coronary blood flow.

特徴および利点

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

物理的形状

ウサギIgGのPBS溶液(Mg2+およびCa2+を含まず)、pH 7.4、150 mM NaCl、0.02% アジ化ナトリウム、50% グリセロール

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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保管分類コード

10 - Combustible liquids

WGK

nwg

引火点(°F)

Not applicable

引火点(℃)

Not applicable


適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

Jan Code

SAB4502010-100UG:


試験成績書(COA)

製品のロット番号・バッチ番号を入力して、試験成績書(COA) を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。

以前この製品を購入いただいたことがある場合

文書ライブラリで、最近購入した製品の文書を検索できます。

文書ライブラリにアクセスする

Anna Svenningsson et al.
Journal of human genetics, 57(2), 115-121 (2011-12-14)
Infantile hypertrophic pyloric stenosis (IHPS) is a common cause of upper gastrointestinal obstruction during infancy. A multifactorial background of the disease is well established. Multiple susceptibility loci including the neuronal nitric oxide synthase (NOS1) gene have previously been linked to
G Catanzaro et al.
Journal of neuroimmunology, 294, 32-40 (2016-05-04)
The development of multiple sclerosis, a major neurodegenerative disease, is due to both genetic and environmental factors that might trigger aberrant epigenetic changes of the genome. In this study, we analysed global DNA methylation in the brain of mice upon
A Kumar et al.
Vitamins and hormones, 103, 147-167 (2017-01-08)
Stress is often marked by a state of hyperarousal to aid the initiation of necessary stress response for the successful management of stressful stimuli. It can be manifested as a challenge (stimulus) that requires behavioral, psychological, and physiological adaptations for
Hideshi Ihara et al.
The Biochemical journal, 474(7), 1149-1162 (2017-01-28)
We previously demonstrated different spacial expression profiles of the neuronal nitric oxide (NO) synthase (nNOS) splice variants nNOS-µ and nNOS-α in the brain; however, their exact functions are not fully understood. Here, we used electron paramagnetic resonance to compare the
Yan Yang et al.
Molecular medicine reports, 13(2), 1220-1226 (2015-12-10)
Spinal nitric oxide is involved in the mechanisms of pain generation and transmission during inflammatory and neuropathic pain. The aim of the present study was to explore the role of spinal nitric oxide in the development of bone cancer pain.

ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.

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