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Merck

SAB4501342

Sigma-Aldrich

Anti-CARD10 antibody produced in rabbit

affinity isolated antibody

別名:

CARD-containing MAGUK protein 3, CARD10, CARMA3, Carma 3, Caspase recruitment domain-containing protein 10

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About This Item

UNSPSCコード:
12352203
NACRES:
NA.41

由来生物

rabbit

品質水準

結合体

unconjugated

抗体製品の状態

affinity isolated antibody

抗体製品タイプ

primary antibodies

クローン

polyclonal

フォーム

buffered aqueous solution

分子量

antigen 115 kDa

交差性

mouse, human

濃度

~1 mg/mL

テクニック

ELISA: 1:1000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000

NCBIアクセッション番号

UniProtアクセッション番号

輸送温度

wet ice

保管温度

−20°C

ターゲットの翻訳後修飾

unmodified

遺伝子情報

human ... CARD10(29775)

詳細

Anti-CARD10 antibody detects endogenous levels of total CARD10 protein.
CARD10 (caspase recruitment domain-containing protein 10) is an important BCL10 (B-cell CLL/lymphoma 10) interactor. It is a member of membrane-associated guanylate kinase family. It is mapped to human chromosome 22q13.1. The CARD10 protein has 1032 amino acids with an estimated molecular weight of 116 kDa. It consists of five putative functional domains, an N-terminal CARD domain, a central coiled-coil domain, and a C-terminal tripartite structure consisting of a PDZ (post synaptic density protein (PSD95), drosophila disc large tumor suppressor (Dlg1) and zonula occludens-1 protein) domain, an SH3 (SRC homology 3 domain) domain, and a GUK (guanylate kinases) domain with homology to guanylate kinase. In several adult tissues, including heart, kidney, and liver, it is expressed as a 4.4-kilobase transcript.

免疫原

The antiserum was produced against synthesized peptide derived from human CARD10.

Immunogen Range: 481-530

生物化学的/生理学的作用

CARD10 (Caspase recruitment domain-containing protein 10) helps to arrange signaling complexes at plasma membrane. It also serves as a molecular scaffold for the assembly of a B-cell CLL/lymphoma 10 (BCL10) signaling complex that activates NF-κB (nuclear factor-κB).

特徴および利点

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

物理的形状

ウサギIgGのPBS溶液(Mg2+およびCa2+を含まず)、pH 7.4、150 mM NaCl、0.02% アジ化ナトリウム、50% グリセロール

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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保管分類コード

10 - Combustible liquids

WGK

nwg

引火点(°F)

Not applicable

引火点(℃)

Not applicable


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文書ライブラリにアクセスする

Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B.
Wang L, et al.
The Journal of Biological Chemistry, 276(24), 21405-21409 (2001)
Genome-wide association studies in Asians confirm the involvement of ATOH7 and TGFBR3, and further identify CARD10 as a novel locus influencing optic disc area.
Khor C C, et al.
Human Molecular Genetics, 20(9), 1864-1872 (2011)

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