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由来生物
rabbit
結合体
unconjugated
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
形状
buffered aqueous solution
分子量
antigen 27 kDa
化学種の反応性
human
濃度
~1 mg/mL
テクニック
ELISA: 1:40000
western blot: 1:500-1:1000
NCBIアクセッション番号
UniProtアクセッション番号
輸送温度
wet ice
保管温度
−20°C
ターゲットの翻訳後修飾
proteolytically cleaved (Pro1426)
遺伝子情報
human ... COL4A3(1285)
詳細
Collagen type IV alpha 3 chain (COL4A3) gene with 52 exons, codes for the α3 chain of type IV collagen. COL4A3 protein is the vital structural protein in the basement membrane. COL4A3 gene is located on human chromosome 2q36.3. Anti-Collagen IV α3 (cleaved-pro1426) antibody detects endogenous levels of fragment of activated collagen IV α3 (cleaved-pro1426) protein.
免疫原
The antiserum was produced against synthesized peptide derived from human Collagen IV alpha3.
Immunogen Range: 1407-1456
Immunogen Range: 1407-1456
生物化学的／生理学的作用
Type IV collagen plays a key role in cell adhesion, proliferation, migration, survival, and differentiation. It maintains the assembly and mechanical stability by acting as a scaffold. Collagen type IV alpha 3 chain (COL4A3) mutations are associated with Alport syndrome (AS). Heterozygous mutations in the COL4A4 gene are observed in individuals with benign familial hematuria (BFH). Alterations in the COL4A3 gene also result in diabetic kidney disease from maturity-onset diabetes.
特徴および利点
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
物理的形状
ウサギIgGのPBS溶液（Mg2+およびCa2+を含まず）、pH 7.4、150 mM NaCl、0.02％ アジ化ナトリウム、50％ グリセロール
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
12 - Non Combustible Liquids
WGK
nwg
引火点(°F)
Not applicable
引火点(℃)
Not applicable
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
C Cervera-Acedo et al.
BMC nephrology, 18(1), 325-325 (2017-11-02)
Alport syndrome is an inherited renal disorder characterized by glomerular basement membrane lesions with hematuria, proteinuria and frequent hearing defects and ocular abnormalities. The disease is associated with mutations in genes encoding α3, α4, or α5 chains of type IV
Laurence Heidet et al.
Journal of the American Society of Nephrology : JASN, 12(1), 97-106 (2001-01-03)
Mutations in either the COL4A3 or the COL4A4 genes, encoding the alpha3 and alpha4 chains of type IV collagen, are responsible for the autosomal-recessive form of Alport syndrome, a progressive hematuric nephropathy characterized by glomerular basement membrane abnormalities. Reported here
Liang Xia et al.
Disease markers, 2019, 8705989-8705989 (2019-03-19)
Mutations in the COL4A3 gene are frequently reported to be associated with various types of hereditary nephropathy. COL4A3 encodes the α3 chain of type IV collagen, which is the main structural protein in the basement membrane. Mutations in this gene
Daniel Öhlund et al.
BMC cancer, 13, 154-154 (2013-03-28)
Pancreatic cancer shows a highly aggressive and infiltrative growth pattern and is characterized by an abundant tumor stroma known to interact with the cancer cells, and to influence tumor growth and drug resistance. Cancer cells actively take part in the
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