SAB4300253

Anti-phospho-SMAD3 (pSer⁴²⁵) antibody produced in rabbit

affinity isolated antibody

• 別名: 抗DKFZp686J10186抗体 ウサギ宿主抗体, 抗HSPC193抗体 ウサギ宿主抗体, 抗HsT17436抗体 ウサギ宿主抗体
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: buffered aqueous solution
• 分子量: ~52 kDa
• 化学種の反応性: mouse, human, rat
• 濃度: 1 mg/mL
• テクニック: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
• アイソタイプ: IgG
• 免疫原配列: (C-S-S-V-SP)
• NCBIアクセッション番号: NP_001138574.1
• UniProtアクセッション番号: P84022
• アプリケーション: research pathology
• 輸送温度: wet ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: phosphorylation (pSer425)
• 遺伝子情報: human ... SMAD3(4088)

詳細

詳細

The SMAD3 (mothers against decapentaplegic homolog 3) gene is mapped to human chromosome 15q22.33. Smad3 protein identifies tandem repeats of the palindromic sequence GTCTAGAC, which is part of TGF-β (Transforming growth factor β) signaling promoter region.

免疫原

Peptide sequence around phosphorylation site of serine 425 (C-S-S-V-S(p)), according to the protein SMAD3.

アプリケーション

Anti-phospho-SMAD3 (pSer425) antibody produced in rabbit has been used in immunoblotting.

生物化学的／生理学的作用

Smad3 (mothers against decapentaplegic homolog 3) is associated with TGF-β (transforming growth factor β) signaling pathway, a cellular process regulating the homeostasis, development, and repair of cartilage. It is known to induce extracellular matrix production. Smad proteins are responsible for the transduction of signals from cell surface to the nucleus. Phosphorylation of Smad3 controls tumor progression, inflammation, fibrosis, obesity and diabetes. Smad3 expression might be associated with the pathogenesis of osteoarthritis.

特徴および利点

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ターゲットの説明

Smad3 encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis.

物理的形状

PBS（0.02％ アジ化ナトリウム、50％ グリセロール含有）

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable