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Merck

SAB4200470

Sigma-Aldrich

Anti-SND1 antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

別名:

Anti-Staphylococcal nuclease and tudor domain containing 1, p100, Anti-TDRD11

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About This Item

UNSPSCコード:
12352203
NACRES:
NA.41

由来生物

rabbit

品質水準

結合体

unconjugated

抗体製品の状態

affinity isolated antibody

抗体製品タイプ

primary antibodies

クローン

polyclonal

フォーム

buffered aqueous solution

分子量

antigen ~102 kDa

化学種の反応性

rat, human, mouse

濃度

~1.0 mg/mL

テクニック

immunoprecipitation (IP): 1-2 μg using lysates of rat NRK cells.
indirect immunofluorescence: 2.5-5.0 μg/mL using human HeLa cells.
western blot: 0.25-0.5 μg/mL using whole extracts of mouse NIH-3T3 cells.

UniProtアクセッション番号

輸送温度

dry ice

保管温度

−20°C

ターゲットの翻訳後修飾

unmodified

遺伝子情報

human ... SND1(27044)
mouse ... snd1(56463)
rat ... snd1(64635)

詳細

Staphylococcal nuclease and tudor domain containing 1 (SND1), also called as Tudor-SN, is encoded by the gene mapped to human chromosome 7q32.1. The encoded protein acts as an important constituent of RNA-induced silencing complex (RISC). SND1 is characterized with an five repeated staphylococcal nuclease homology domains and a Tudor-homology domain involved in interaction of nucleic acids and proteins, respectively.
The SND1 protein is a part of the RNA-induced silencing complex (RISC). It is highly conserved from yeast to human.

特異性

Anti-SND1 recognizes human, rat and mouse SND1.

免疫原

peptide corresponding to an internal region of human SND1, conjugated to KLH. The corresponding sequence differs by a single amino acid in mouse and rat.

アプリケーション

Anti-SND1 antibody produced in rabbit may be used in:
  • immunoblotting
  • immunoprecipitation
  • immunofluorescence

生物化学的/生理学的作用

SND1 protein plays a vital role in the degradation of hyper-edited inosine containing miRNA precursors. It also controls miRNA processing and expression through RNA editing by adenosine deaminase acting on RNA (ADAR).
Staphylococcal nuclease and tudor domain containing 1 (SND1) interacts with RNA in some sequence-specific manner and regulates the gene expression at both transcriptional and posttranscriptional levels. The encoded protein plays a key role in gene transcription and mRNA metabolism. Additionally, it is also implicated in maintenance of cellular cholesterol distribution and homeostasis in hepatoma cells. SND1 facilitates various RNA functions such as, RNA maturation, spliceosome assembly,pre-mRNA splicing, RNA stability and RNA editing. It is also involved in RNA interference,microRNA processing, response to environmental and metabolic stressors and lipoprotein lipid secretion. Overexpression of the gene has been observed in human colon cancers and hepatocellular carcinoma cells.

物理的形状

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

保管および安定性

For continuous use, store at 2-8°C for up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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保管分類コード

10 - Combustible liquids

WGK

WGK 2

引火点(°F)

Not applicable

引火点(℃)

Not applicable


適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

Jan Code

SAB4200470-VAR:
SAB4200470-200UL:
SAB4200470-BULK:


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試験成績書(COA)

Lot/Batch Number

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以前この製品を購入いただいたことがある場合

文書ライブラリで、最近購入した製品の文書を検索できます。

文書ライブラリにアクセスする

SND1, a Component of RNA-Induced Silencing Complex, Is Up-regulated in Human Colon Cancers and Implicated in Early Stage Colon Carcinogenesis
Tsuchiya N
Cancer Research, 67, 9568-9576 (2007)
SND1 overexpression deregulates cholesterol homeostasis in hepatocellular carcinoma.
Navarro-Imaz H
Biochimica et Biophysica Acta, 1861, 988-996 (2016)
Prognostic implication of MET overexpression in myxofibrosarcomas: an integrative array comparative genomic hybridization, real-time quantitative PCR, immunoblotting, and immunohistochemical analysis.
Lee JC
Modern Pathology, 23, 1379-1392 (2010)
Expression analysis of Tudor-SN protein in mouse tissues
Fashe T, et al.
Tissue & cell, 45(1), 21-31 (2013)
Enara Arretxe et al.
Nucleic acids research, 43(22), 10673-10688 (2015-09-02)
The NF-κB-inducible Staphylococcal nuclease and tudor domain-containing 1 gene (SND1) encodes a coactivator involved in inflammatory responses and tumorigenesis. While SND1 is known to interact with certain transcription factors and activate client gene expression, no comprehensive mapping of SND1 target

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