SAB4200344

Anti-SMYD3 antibody, Mouse monoclonal

clone SMYD3-2, purified from hybridoma cell culture

• 別名: 抗SET・ MYNDドメイン含有分子3抗体, 抗ZMYND1抗体
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: mouse
• 結合体: unconjugated
• 抗体製品の状態: purified from hybridoma cell culture
• 抗体製品タイプ: primary antibodies
• クローン: SMYD3-2, monoclonal
• 形状: buffered aqueous solution
• 分子量: antigen ~43 kDa
• 化学種の反応性: rat, mouse, human
• 濃度: ~1.0 mg/mL
• テクニック: western blot: 5-10 μg/mL using whole extracts of HeLa cells
• アイソタイプ: IgG1
• UniProtアクセッション番号: Q9H7B4
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... SMYD3(64754) ; mouse ... Smyd3(69726) ; rat ... Smyd3(498295)

詳細

詳細

Monoclonal Anti-SMYD3 (mouse IgG1 isotype) is derived from the hybridoma SMYD3-2 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a fusion protein corresponding to a fragment of human SMYD3. SMYD3 belongs to the SMYD family of chromatin regulators. It is a histone methyltransferase, that plays a role in transcriptional regulation as a member of an RNA polymerase complex. SMYD3 contains a SET domain, which is critical for the methylation of histone H3 at Lys⁴ and a myeloid, Nervy, and DEAF-1 (MYND)-type zinc-finger domain, which is common to developmental proteins.

免疫原

Fusion protein corresponding to a fragment of human SMYD3.

アプリケーション

Monoclonal Anti-SMYD3 antibody produced in mouse has been used in immunoblotting and immunoprecipitation.

生物化学的／生理学的作用

SMYD3 is important in heart and skeletal muscle development. Overexpression of SMYD3 is observed in hepatocellular cancer, colorectal cancer and breast cancer. SMYD3 is essential for estrogen receptor-regulated gene transcription in the estrogen signaling pathway.

物理的形状

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide as a preservative.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable