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詳細
Rift valley fever virus (RVFV) is an enveloped RNA virus belonging to the Phlebovirus genus of the family Bunyaviridae. RVFV possesses a single stranded segmented RNA genome composed of a large (L), a medium (M), and a small (S) segment. The L segment codes for the RNA-dependent RNA polymerase. The M segment codes for a polyprotein which is the precursor to the glycoproteins G1 and G2 and two non-structural proteins, 14K and 78K. The S segment codes for the nucleoprotein N and the non-structural protein NSs.
免疫原
Antibody was raised against a 20 amino acid synthetic peptide near the center of the RVF virus.
生物化学的／生理学的作用
Rift valley fever virus (RVFV) causes rift valley fever (RVF), an arthropod-borne viral disease. The virus is transmitted either by an arthropod or direct transmission by contact or aerosol among the hosts. The non-structural phosphoprotein (NSs) is responsible for the virulence in the pathogenic RVFV and suppresses human interferon gene expression. The fever is mainly observed in sheep and cattle. In humans, RVF clinical symptoms includes benign fever to severe encephalitis, retinitis, and fatal hepatitis with haemorrhagic fever. RVFV may block α/β interferon (IFN-α/β) expression in host and may target transcription factor aswell TFIIH.
特徴および利点
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
関連事項
The action of this antibody can be blocked using blocking peptide SBP3500929.
物理的形状
1 mg/mLのPBS溶液（0.02％アジ化ナトリウム含有）
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
SAB3500929-100UG:
最新バージョンのいずれかを選択してください：
NSs protein of Rift Valley fever virus blocks interferon production by inhibiting host gene transcription
Billecocq A, et al.
Journal of Virology, 78(18), 9798-9806 (2004)
Mutagen-directed attenuation of Rift Valley fever virus as a method for vaccine development
Caplen H, et al.
The Journal of General Virology, 66, 2271-2277 (1985)
Genetic evidence for an interferon-antagonistic function of rift valley fever virus non-structural protein NSs
Bouloy M, et al.
Journal of Virology, 75(3), 1371-1377 (2001)
C Giorgi et al.
Virology, 180(2), 738-753 (1991-02-01)
The sequences and coding strategies of the S RNAs of two viruses, Toscana (TOS) and the M12 derivative of Rift Valley fever ZH-548 (RVF, Phlebovirus genus, Bunyaviridae) have been determined from cDNA clones and compared to the previously published sequences
Global Trade Item Number
| カタログ番号 | GTIN |
|---|---|
| SBP3500929-0.05MG | 4061832173832 |
| SAB3500929-100UG | 4061832497471 |
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