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由来生物
rabbit
結合体
unconjugated
抗体製品の状態
IgG fraction of antiserum
抗体製品タイプ
primary antibodies
クローン
polyclonal
形状
buffered aqueous solution
分子量
antigen ~20 kDa
化学種の反応性
human
テクニック
indirect immunofluorescence: suitable
western blot: 1:500-1:2,000
UniProtアクセッション番号
輸送温度
dry ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... ARPC4(10093)
詳細
Actin related protein 2/3 complex, subunit 4 (ARPC4) is mapped to human chromosome 3p25.3. It is part of the ARP2/3 complex which connects this complex to the mother filament.
免疫原
synthetic peptide corresponding to amino acids 26-40 of human ARPC4
アプリケーション
Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if.
生物化学的／生理学的作用
Actin related protein 2/3 complex, subunit 4 (ARPC4) in plants is crucial for action dynamics and cordinates the tip growth and movement. It is highly expressed in most of the pancreatic carcinoma and may regulate cancer cell migration. It interacts with mycobacterial protein Rv1626 and its expression in Mycobacterium tuberculosis impacts its survival and infection profile, making it an effective anti-tuberculosis drug candidate.
物理的形状
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
WGK 2
引火点(°F)
Not applicable
引火点(℃)
Not applicable
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Expression of the ARPC4 subunit of human Arp2/3 severely affects Mycobacterium tuberculosis growth and suppresses immunogenic response in murine macrophages
Ghosh A, et al.
Testing, 8(7), e69949-e69949 (2013)
The role of ARPC4 in tip growth and alignment of the polar axis in filaments of Physcomitrella patens
Perroud PF and Quatrano RS
Cell Motility and the Cytoskeleton, 63(3), 162-171 (2006)
Silencing of the ARP2/3 complex disturbs pancreatic cancer cell migration
Rauhala HE, et al.
Anticancer Research, 33(1), 45-52 (2013)
3p- syndrome defines a hearing loss locus in 3p25.3
McCullough BJ, et al.
Hearing Research, 224(1-2), 51-60 (2007)
Chiara Galloni et al.
The Journal of cell biology, 220(8) (2021-06-10)
The mechanisms regulating the disassembly of branched actin networks formed by the Arp2/3 complex still remain to be fully elucidated. In addition, the impact of Arp3 isoforms on the properties of Arp2/3 are also unexplored. We now demonstrate that Arp3
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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