S6451

SCH-442416

≥98% (HPLC)

• 別名: 2-(2-Furanyl)-7-[3-(4-methoxyphenyl)propyl]-7H-pyrazolo [4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine; 5-amino-7-(3-(4-methoxyphenyl)propyl)-2-(2 furyl)pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine; 5-Amino-7-[3-(4-methoxy)phenylpropyl]-2-(2-furyl)-pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine
• 実験式（ヒル表記法）: C₂₀H₁₉N₇O₂
• CAS番号: 316173-57-6
• 分子量: 389.41
• MDL番号: MFCD08703126
• UNSPSCコード: 12352200
• PubChem Substance ID: 329824564
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 保管条件: desiccated
• 色: light tan to tan
• 溶解性: DMSO: ≥20 mg/mL
• 保管温度: 2-8°C
• SMILES記法: COc1ccc(CCCn2ncc3c2nc(N)n4nc(nc34)-c5ccco5)cc1
• InChI: 1S/C20H19N7O2/c1-28-14-8-6-13(7-9-14)4-2-10-26-18-15(12-22-26)19-23-17(16-5-3-11-29-16)25-27(19)20(21)24-18/h3,5-9,11-12H,2,4,10H2,1H3,(H2,21,24)
• InChI Key: AEULVFLPCJOBCE-UHFFFAOYSA-N

詳細

アプリケーション

SCH-442416 has been used:

• as a selective adenosine A2A antagonist to study its effects on cyclic adenosine monophosphate (cAMP) production in T/C-28a2 chondrocytes or hFOB 1.19 osteoblasts 
• as a presynaptic A2A receptor antagonists to study its effects on receptor blockade on δ9-Tetrahydrocannabinol (THC) self-administration in squirrel monkeys
• as a presynaptic A2A receptor antagonists to study its effects on cocaine-induced locomotion and cocaine-seeking in mice

生物化学的／生理学的作用

SCH-442416は、アデノシンA2a受容体の強力かつ選択的なアンタゴニストです。A2aに対するKi値は0.048であり、他のアデノシン受容体と比較してA2aに対し10,000倍を越える選択性を示しています。

特徴および利点

This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable